ArticleProceedings. Biological sciences2018
Adaptive periodicity in the infectivity of malaria gametocytes to mosquitoes.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick-borne filarial nematode transmission.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Biting time of day in malaria mosquitoes is modulated by nutritional status.Malaria journal · 2025Article
- Biting time of day in malaria mosquitoes is modulated by nutritional status.bioRxiv : the preprint server for biology · 2025Article
- Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts.Parasites & vectors · 2025Article
- Modelling the effects of diurnal temperature variation on malaria infection dynamics in mosquitoes.Communications biology · 2025Article
- Phenotypic and fitness consequences of plasticity in the rhythmic replication of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Melatonin as a Circadian Marker forInternational journal of molecular sciences · 2024Review
- Testing the evolutionary drivers of malaria parasite rhythms and their consequences for host-parasite interactions.Evolutionary applications · 2024Article
- Circadian and daily rhythms of disease vector mosquitoes.Current opinion in insect science · 2024Review
- Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria.iScience · 2024Article
- Virulence is associated with daily rhythms in the within-host replication of the malaria parasiteEvolutionary applications · 2024Article
- Testing a non-destructive assay to track Plasmodium sporozoites in mosquitoes over time.Parasites & vectors · 2023Article
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia.Parasites & vectors · 2022Article
- Mistimed malaria parasites re-synchronize with host feeding-fasting rhythms by shortening the duration of intra-erythrocytic development.Parasite immunology · 2022Review
- The circadian clock modulates Anopheles gambiae infection with Plasmodium falciparum.PloS one · 2022Article
- Malaria parasites and circadian rhythm: New insights into an old puzzle.Current research in microbial sciences · 2021Article
- The Impact of Temperature on the Sporogonic Development of the Tropical Avian Malaria ParasiteMicroorganisms · 2021Article
- The private life of malaria parasites: Strategies for sexual reproduction.Molecular and biochemical parasitology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Daily rhythms in behaviour, physiology and molecular processes are expected to enable organisms to appropriately schedule activities according to consequences of the daily rotation of the Earth. For parasites, this includes capitalizing on periodicity in transmission opportunities and for hosts/vectors, this may select for rhythms in immune defence. We examine rhythms in the density and infectivity of transmission forms (gametocytes) of rodent malaria parasites in the host's blood, parasite development inside mosquito vectors and potential for onwards transmission. Furthermore, we simultaneously test whether mosquitoes exhibit rhythms in susceptibility. We reveal that at night, gametocytes are twice as infective, despite being less numerous in the blood. Enhanced infectiousness at night interacts with mosquito rhythms to increase sporozoite burdens fourfold when mosquitoes feed during their rest phase. Thus, changes in mosquito biting time (owing to bed nets) may render gametocytes less infective, but this is compensated for by the greater mosquito susceptibility.
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