ArticlePsychological medicine2019
Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2021Pooled it
- Pooled it
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- Article
- Integrating Transdiagnostic and Biopsychosocial Approaches to Move Beyond Categorical Diagnoses in Neurodevelopmental Disorders: A Perspective Review.PsyCh journal · 2026Review
- Concordance of positive, negative and disorganised psychotic syndromes in five twin samples.BJPsych open · 2026Article
- Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study.Schizophrenia bulletin · 2025Article
- Transdiagnostic Symptom Dimensions in Individuals at Ultra-High Risk for Psychosis: Towards Dimensional Representations of Pluripotent Risk.Early intervention in psychiatry · 2025Article
- Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study.Clinical neuropsychiatry · 2025Article
- Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples.The British journal of psychiatry : the journal of mental science · 2025Article
- The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis.Translational psychiatry · 2024Article
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- The role of interpersonal trauma and substance use in mental health: A large population-based study.Psychiatry research · 2024Article
- Urbanicity and psychotic disorders: Facts and hypotheses.Dialogues in clinical neuroscience · 2023Review
- The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis.Psychological medicine · 2023Article
- Cannabis use and psychotic disorders in diverse settings in the Global South: findings from INTREPID II.Psychological medicine · 2023Article
- Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study.Psychological medicine · 2023Article
- Differences in clinical presentation at first hospitalization and the impact on involuntary admissions among first-generation migrant groups with non-affective psychotic disorders.Social psychiatry and psychiatric epidemiology · 2023Article
- Personality functioning and self-disorders in individuals at ultra-high risk for psychosis, with first-episode psychosis and with borderline personality disorder.BJPsych open · 2023Article
- Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.Psychological medicine · 2023Article
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38 authors.
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Abstract
backgroundThe value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment.
methodThis study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions.
resultsA bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions.
conclusionsOur results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum.
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