ArticleThe Journal of neuropsychiatry and clinical neurosciences2019
Resting-State Functional Connectivity of the Habenula in Mood Disorder Patients With and Without Suicide-Related Behaviors.
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Article in The Journal of neuropsychiatry and clinical neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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28citing papers in PubMed, 2 pooled it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Irritability as an independent predictor of concurrent and future suicidal ideation in adults with stimulant use disorder: Findings from the STRIDE study.Journal of affective disorders · 2021Trial
- Habenula Connectivity and Intravenous Ketamine in Treatment-Resistant Depression.The international journal of neuropsychopharmacology · 2021Trial
- Habenular structural-functional dysconnectivity in bipolar disorder: evidence from multimodal imaging and transcriptomic integration.BMC psychiatry · 2026Article
- The Habenula's role in major depressive disorder: recent insights from preclinical and human studies.Translational psychiatry · 2026Review
- Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data.Brain sciences · 2025Review
- Functional brain connectivity of the salience network in alcohol use and anxiety disorders.Journal of affective disorders · 2025Article
- Integrative Functions of the Hypothalamus: Linking Cognition, Emotion and Physiology for Well-being and Adaptability.Annals of neurosciences · 2025Review
- Reward Processing in Psychiatric Inpatients With Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.Psychological medicine · 2023Article
- Suicide prevention and ketamine: insights from computational modeling.Frontiers in psychiatry · 2023Review
- miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder.Npj mental health research · 2023Article
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder.Frontiers in psychiatry · 2022Article
- The Role of the Lateral Habenula in Suicide: A Call for Further Exploration.Frontiers in behavioral neuroscience · 2022Review
- Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation.Frontiers in neuroscience · 2022Article
- Commentary: Aberrant dynamic functional connectivity of posterior cingulate cortex subregions in major depressive disorder with suicidal ideation.Frontiers in neuroscience · 2022Article
- Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
- A Computational Model of Hopelessness and Active-Escape Bias in Suicidality.Computational psychiatry (Cambridge, Mass.) · 2022Article
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Authors and funding
10 authors.
Elisa AmbrosiFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
David B ArciniegasFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Kaylah N CurtisFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Michelle A PatriquinFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Gianfranco SpallettaFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Gabriele SaniFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
B Christopher FruehFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
J Christopher FowlerFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Alok MadanFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Ramiro SalasFrom the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (EA, DAB, KNC, MAP, GiSp, JCF, AM, RS); Department of Neurosciences, Baylor College of Medicine, Houston; the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Baylor College of Medicine, Houston (EA, DAB, GiSp);the Menninger Clinic, Houston (MAP); the Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome Italy (GiSp); Centro Lucio Bini, Roma, Italy (GaSa); the Michael E. DeBakey VA Medical Center, Houston (KNC, MAP, RS); the Department of Neurosciences, Mental Health, and Sensory Organs, Sapienza University, Rome (GaSa); the School of Medicine and Psychology, Sant' Andrea Hospital, Rome (GaSa); Tufts Medical Center, Tufts University School of Medicine, Boston (GaSa); and the Department of Psychology, University of Hawaii, Hilo, HI (BCF), Trauma and Resilience Center, Department of Psychiatry and Behavioral Sciences, University of Texas Health Sciences Center, Houston (BCF).
Funding
Role of Habenula in Tobacco AddictionK01DA026539 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI SALAS, RAMIRO · 2010 to 2013
$516kFunctional Imaging of the Habenula in Tobacco SmokersR03DA029167 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI SALAS, RAMIRO · 2011 to 2011
$230kMultimodal Imaging of Reward Brain Centers in Tobacco Smoking VeteransI01CX000994 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI SALAS, RAMIRO · 2014 to 2016
–CSRD VA I01 CX000994NIDA NIH HHS K01 DA026539NIDA NIH HHS R03 DA029167
Abstract
The habenula is a small midbrain structure that is important for brain signaling and learning from negative events. Thus, the habenula is strongly connected to both the reward system and motor regions. Increasing evidence suggests a role for the habenula in the etiology of psychiatric disorders, including mood and substance use disorders. However, no studies to date have investigated habenular resting-state functional connectivity (rsFC) in suicide-related behaviors (SB). The authors enrolled 123 individuals with major depressive disorder (MDD) or bipolar disorder and a history of suicide-related behaviors (SB+), 74 individuals with MDD or bipolar disorder and a history of suicidal ideation but no history of SB (SB-), and 75 healthy control subjects (HC). A seed-based approach was used to identify regions showing different rsFC with the habenula followed by region of interest to region of interest post hoc comparisons. Compared with both the SB- and HC groups, the SB+ group showed higher connectivity between the left habenula and the left parahippocampal gyrus, the right amygdala, and the right precentral and postcentral gyri. Patients with mood disorders displayed higher rsFC between the left habenula and left middle temporal gyrus, the left angular gyrus, and the left posterior cingulate cortex, as well as lower rsFC between the right habenula and the left thalamus, when compared with HCs. These findings suggest that the habenula is involved in the neural circuitry of suicide. The higher habenular rsFC found in the SB+ group may mediate a dysfunction in the mechanism that links the habenula with motor activity and contextual associative processing.
Indexed as
Suicidal IdeationSuicide, AttemptedAdultAmygdalaBipolar DisorderCerebral CortexConnectomeFemaleHabenulaHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleThalamusBipolar DisorderHabenulaMajor Depressive DisorderResting-State fMRISuicide
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