Evidence map›Paper›PMID 30282506›Full record

ArticleInternational journal of toxicology

Embracing Transparency Through Data Sharing.

Stéphanie Boué, Michael Byrne, A Wallace Hayes, Julia Hoeng, Manuel C Peitsch

Open access · hybridAbstract read
In one paragraph

Article in International journal of toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Stéphanie BouéPMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.ORCID http://orcid.org/0000-0003-0680-4168
Michael ByrneGlobal Biological Standards Institute (GBSI), Washington, DC, USA.
A Wallace HayesMichigan State University, Institute for Integrative Toxicology, East Lansing, MI, USA.
Julia HoengPMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
Manuel C PeitschPMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.
Philip Morris International (Switzerland) · CHGlobal Biological Standards Institute · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low rates of reproducibility and translatability of data from nonclinical research have been reported. Major causes of irreproducibility include oversights in study design, failure to characterize reagents and protocols, a lack of access to detailed methods and data, and an absence of universally accepted and applied standards and guidelines. Specific areas of concern include uncharacterized antibodies and cell lines, the use of inappropriate sampling and testing protocols, a lack of transparency and access to raw data, and deficiencies in the translatability of findings to the clinic from studies using animal models of disease. All stakeholders-academia, industry, funding agencies, regulators, nonprofit entities, and publishers-are encouraged to play active roles in addressing these challenges by formulating and promoting access to best practices and standard operating procedures and validating data collaboratively at each step of the biomedical research life cycle.

Indexed as

antibodydata sharingreproducibilitytranslatabilitytransparency

Identifiers

PMID30282506
PMCPMC6291903
OpenAlexW2894555894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.