Evidence map›Paper›PMID 30282455›Full record

ArticleJournal of the American Chemical Society2018

Sacrificial Cobalt-Carbon Bond Homolysis in Coenzyme B

Gregory C Campanello, Markus Ruetz, Greg J Dodge, Harsha Gouda, Aditi Gupta, Umar T Twahir, Michelle M Killian, David Watkins, David S Rosenblatt, Thomas C Brunold and 3 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. CLYBL averts vitamin BNature chemical biology · 2025
    Article
  4. Article
  5. Article
  6. Cobalt-Sulfur Coordination Chemistry Drives BJournal of the American Chemical Society · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Bivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme BProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Human BMethods in enzymology · 2022
    Article
  13. The human BMethods in enzymology · 2022
    Article
  14. Redox-Linked Coordination Chemistry Directs Vitamin BAccounts of chemical research · 2021
    Article
  15. Article
  16. Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme BProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Gregory C CampanelloDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.
Markus RuetzDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.
Greg J DodgeDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.
Harsha GoudaDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.
Aditi GuptaDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.
Umar T TwahirDepartment of Physics , Emory University , Atlanta , Georgia 30322-2430 , United States.
Michelle M KillianDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
David WatkinsDepartment of Human Genetics , McGill University , Montreal , Quebec H3A 1B1 , Canada.
David S RosenblattDepartment of Human Genetics , McGill University , Montreal , Quebec H3A 1B1 , Canada.
Thomas C BrunoldDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0001-6516-598X
Kurt WarnckeDepartment of Physics , Emory University , Atlanta , Georgia 30322-2430 , United States.ORCID 0000-0002-3587-3720
Janet L SmithDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.ORCID 0000-0002-0664-9228
Ruma BanerjeeDepartment of Biological Chemistry , University of Michigan , Ann Arbor , Michigan 48109-0600 , United States.ORCID 0000-0001-8332-3275
University of Michigan · USEmory University · USMcGill University · CAUniversity of Wisconsin–Madison · USIndian Institute of Science Education and Research Pune · IN

Funding

REACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7M
Co(II)-Radical Pair Dynamics in B12 Enzyme CatalysisR01DK054514 · NIDDK · EMORY UNIVERSITY · PI WARNCKE, KURT · 1998 to 2019
$4.2M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
Investigation of management and disease manifestations of viral hepatitisZ01DK054514 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2007 to 2008
$838k
Silicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490k
Co(II)-Radical Pair Dynamics in B12 Enzyme CatalysisR56DK054514 · NIDDK · EMORY UNIVERSITY · PI WARNCKE, KURT · 2008 to 2014
$151k
Structural Enzymology of Mitochondrial B12 Trafficking ProteinsF32GM113405 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPANELLO, GREGORY · 2015 to 2016
$112k
Intramural NIH HHS Z01 DK054514NIDDK NIH HHS R01 DK045776NIDDK NIH HHS R01 DK054514NIDDK NIH HHS R56 DK054514NIGMS NIH HHS F32 GM113405NIH HHS S10 OD012289NIH HHS S10 OD020011
6 · The paper itself

Abstract

A sophisticated intracellular trafficking pathway in humans is used to tailor vitamin B

Indexed as

Alkyl and Aryl TransferasesCarbonCatalytic DomainCobaltCobamidesFibroblastsHumansMethylmalonyl-CoA MutaseMolecular StructureAlkyl and Aryl TransferasesCarbonCobaltCobamidescob(I)alamin adenosyltransferaseMethylmalonyl-CoA Mutase

Identifiers

PMID30282455
PMCPMC6743335
OpenAlexW2895370134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.