Evidence map›Paper›PMID 30282369›Full record

ArticleJournal of Alzheimer's disease : JAD2018

Genetic Risk of Alzheimer's Disease: Three Wishes Now That the Genie is Out of the Bottle.

Lori Frank, J Wesson Ashford, Peter J Bayley, Soo Borson, Herman Buschke, Donna Cohen, Jeffrey L Cummings, Peter Davies, Margaret Dean, Sanford I Finkel and 4 more

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Psychological impacts of APOE genotype disclosure among Latinos in New York City: a randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  2. Article
  3. Review
  4. Article
  5. Communicating and Using Dementia Risk Evidence.Journal of Alzheimer's disease : JAD · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lori FrankHealth and Aging Policy Fellow/American Political Science Association Congressional Fellow; Senior Advisor, PCORI, Bethesda, MD, USA.
J Wesson AshfordDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA and War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Peter J BayleyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA and War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA.
Soo BorsonUniversity of Washington School of Medicine, University of Washington, Seattle, WA, USA and University of Minnesota, Minneapolis, MN, USA.
Herman BuschkeThe Saul R. Korey Department of Neurology and Dominick P. Purpura Department of Neuroscience, Lena and Joseph Gluck Distinguished Scholar in Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Donna CohenDepartment of Child & Family Studies, College of Behavioral & Community Sciences, University of South Florida, Tampa, FL, USA.
Jeffrey L CummingsCenter for Neurodegeneration and Translational Neuroscience, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NY, USA.
Peter DaviesLitwin-Zucker Center for Alzheimer's Disease & Memory Disorders, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Margaret DeanTexas Tech University Health Sciences Center, Internal Medicine, Amarillo, TX, USA.
Sanford I FinkelDepartment of Psychiatry, University of Chicago Medical School, Chicago, IL, USA.
Lee HyerDepartment of Psychiatry, Mercer School of Medicine, Macon, GA, USA.
George PerryBrain Health Consortium, Department Biology and Chemistry, University of Texas at San Antonio, San Antonio, TX, USA.
Richard E PowersDepartments of Pathology and Psychiatry, University of Alabama School of Medicine, Birmingham, AL, USA.
Frederick SchmittUniversity of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA.

Funding

University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI SCHMITT, FREDERICK · 2006 to 2020
$23.3M
NIA NIH HHS P30 AG028383
6 · The paper itself

Abstract

The availability and increasing popularity of direct-to-consumer genetic testing for the presence of an APOE4 allelle led the Alzheimer's Foundation of America Medical, Scientific and Memory Screening Advisory Board to identify three critical areas for attention: 1) ensure consumer understanding of test results; 2) address and limit potential negative consequences of acquiring this information; and 3) support linking results with positive health behaviors, including potential clinical trial participation. Improving access to appropriate sources of genetic counseling as part of the testing process is critical and requires action from clinicians and the genetic testing industry. Standardizing information and resources across the industry should start now, with the input of consumers and experts in genetic risk and health information disclosure. Direct-to-consumer testing companies and clinicians should assist consumers by facilitating consultation with genetic counselors and facilitating pursuit of accurate information about testing.

Indexed as

Genetic Predisposition to DiseaseAlzheimer DiseaseApolipoprotein E4Genetic TestingHumansRisk FactorsApolipoprotein E4APOEgenetic riskgenetic testinglate-onset Alzheimer’s disease

Identifiers

PMID30282369
PMCPMC6218128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.