ArticleJournal of Alzheimer's disease : JAD2018
Class-Specific Incidence of All-Cause Dementia and Alzheimer's Disease: A Latent Class Approach.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Application of predictive models in boosting power of Alzheimer's disease clinical trials: A post hoc analysis of phase 3 solanezumab trials.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Diagnosing Mild Cognitive Impairment Among Racially Diverse Older Adults: Comparison of Consensus, Actuarial, and Statistical Methods.Journal of Alzheimer's disease : JAD · 2022Article
- Using Mixture Modeling to Construct Subgroups of Cognitive Aging in the Wisconsin Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Latent Cognitive Class at Enrollment Predicts Future Cognitive Trajectories of Decline in a Community Sample of Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women.Journal of Alzheimer's disease : JAD · 2021Article
- Detecting biological heterogeneity patterns in ADNI amnestic mild cognitive impairment based on volumetric MRI.Brain imaging and behavior · 2020Article
- Predicting Amyloid-β Levels in Amnestic Mild Cognitive Impairment Using Machine Learning Techniques.Journal of Alzheimer's disease : JAD · 2020Article
- A Latent Transition Analysis Model to Assess Change in Cognitive States over Three Occasions: Results from the Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2020Article
- Machine Learning Predictive Models Can Improve Efficacy of Clinical Trials for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Neuropsychological latent classes at enrollment and postmortem neuropathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Identifying preclinical Alzheimer's disease (AD) is an important step toward developing approaches to early treatment and dementia prevention. We applied latent class analysis (LCA) to 10 baseline neuropsychological assessments for 1,345 participants from Einstein Aging Study. Time-to-event models for all-cause dementia and AD were run examining events in 4-year intervals. Five classes were identified: Mixed-Domain Impairment (n = 107), Memory-Specific Impairment (n = 457), Average (n = 539), Frontal Impairment (n = 118), and Superior Cognition (n = 124). Compared to the Average class, the Mixed-Domain Impairment and Memory-Specific Impairment classes were at higher risk of incident all-cause dementia and AD in the first 4 years from baseline, while the Frontal Impairment class was associated with higher risk between 4 and 8 years of follow-up. LCA identified classes which differ in cross-sectional cognitive patterns and in risk of dementia over specific follow-up intervals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.