ArticleJournal of Alzheimer's disease : JAD2018
Amyloid and FDG PET of Successful Cognitive Aging: Global and Cingulate-Specific Differences.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Defining exceptional cognition in older adults: A systematic review of cognitive super-ageing.International journal of geriatric psychiatry · 2023Pooled it
- Understanding brain resilience in superagers: a systematic review.Neuroradiology · 2021Pooled it
- Systemic brain-body metabolic coupling patterns in amyotrophic lateral sclerosis: a whole-body [European journal of nuclear medicine and molecular imaging · 2026Article
- Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging.Frontiers in aging neuroscience · 2026Article
- Amyloid burden, brain metabolism, and gray matter volume in SuperAgers.Arquivos de neuro-psiquiatria · 2026Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.Molecular neurodegeneration · 2024Article
- Resilience to AD pathology in Top Cognitive Performers.Frontiers in aging neuroscience · 2024Article
- Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics.Brain sciences · 2023Article
- Axonal energy metabolism, and the effects in aging and neurodegenerative diseases.Molecular neurodegeneration · 2023Review
- Functional activation features of memory in successful agers across the adult lifespan.NeuroImage · 2022Article
- The functional connectivity of basal forebrain is associated with superior memory performance in older adults: a case-control study.BMC geriatrics · 2022Article
- Amyloid-β PET Classification on Cognitive Aging Stages Using the Centiloid Scale.Molecular imaging and biology · 2022Article
- PET imaging of neural activity, β-amyloid, and tau in normal brain aging.European journal of nuclear medicine and molecular imaging · 2021Review
- Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology.NeuroImage. Clinical · 2020Article
- Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSome individuals, called Supernormals (SN), maintain excellent memory in old age. While brain structural and functional integrity in SN seem to be aging-resistant, their amyloidosis and neural injury status has not been well studied.
objectiveThe goal of this study was to compare cortical amyloid deposition and glucose metabolism between SN and older adults with normal cognition (NC), amnestic mild cognitive impairment (MCI), and Alzheimer's disease (AD).
methodsSubjects from the ADNI database were included if they received T1-weighted MRI, amyloid PET, FDG-PET, and cognitive testing within a 6-month period, yielding 27 AD, 69 MCI, 172 NC, and 122 SN. PET standardized uptake value ratios (SUVrs) were calculated for the whole cortex and 68 regions of interest, with whole cerebellum serving as reference.
resultsSN had lower whole cortex amyloid than MCI, and higher glucose metabolism than all others. Regional analysis revealed that amyloid burden and glucose metabolism in the right isthmus cingulate cortex differed in SN compared to others, while SN glucose metabolism also differed from others in several frontal and temporal regions.
conclusionPreserved cortical glucose metabolism, and lower levels of amyloidosis and glucose hypometabolism in the right isthmus cingulate cortex, contributes to the Supernormal phenomenon. These findings may be informative for development of early screening biomarkers and therapeutic targets for modification of cognitive trajectories.
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