Evidence map›Paper›PMID 30282055›Full record

ArticleContemporary clinical trials2018

Vitamin D and omega-3 trial to prevent and treat diabetic kidney disease: Rationale, design, and baseline characteristics.

Ian H de Boer, Leila R Zelnick, Julie Lin, Debra Schaumberg, Lu Wang, John Ruzinski, Georgina Friedenberg, Julie Duszlak, Vadim Y Bubes, Andrew N Hoofnagle and 5 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Ian H de BoerDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, United States. Electronic address: deboer@u.washington.edu.
Leila R ZelnickDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, United States.
Julie LinRenal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Debra SchaumbergReal World Evidence, Evidera, PPD, Waltham MA, Department of Epidemiology, Harvard TH Chan School of Public Health, Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Boston, MA, United States.
Lu WangDepartment of Global Epidemiology, Janssen Research & Development LLC, Titusville, NJ, United States.
John RuzinskiKidney Research Institute, University of Washington, Seattle, WA, United States.
Georgina FriedenbergDivision of Preventive Medicine, Brigham and Women's Hospital, MA, USA.
Julie DuszlakDivision of Preventive Medicine, Brigham and Women's Hospital, MA, USA.
Vadim Y BubesDivision of Preventive Medicine, Brigham and Women's Hospital, MA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Kidney Research Institute, University of Washington, Seattle, WA, United States.
Ravi ThadhaniCedars-Sinai Medical Center, Los Angeles, CA, United States.
Robert J GlynnDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Julie E BuringDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Howard D SessoDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
JoAnn E MansonDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Brigham and Women's Hospital · USUniversity of Washington · USCedars-Sinai Medical Center · USHarvard University · USJanssen (United States) · USUniversity of Utah · US

Funding

VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney diseaseR01DK088762 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2010 to 2019
$4.7M
Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and HypertensionR01HL102122 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FORMAN, JOHN P, SESSO, HOWARD D · 2011 to 2016
$3.3M
NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NHLBI NIH HHS R01 HL102122NIDDK NIH HHS R01 DK088762
6 · The paper itself

Abstract

Diabetic kidney disease (DKD), defined as reduced glomerular filtration rate (GFR), elevated urine albumin excretion, or both that is clinically attributable to diabetes, is a common and morbid diabetes complication. Animal-experimental data, observational human studies, and short-term clinical trials suggest that vitamin D and omega-3 fatty acid supplements may be safe and inexpensive interventions to reduce the incidence and progression of DKD. The Vitamin D and Omega-3 Trial to Prevent and Treat DKD (VITAL-DKD) was designed as an ancillary study to the VITAL trial of 25,871 US adults. In a 2 × 2 factorial design, VITAL participants were randomly assigned to vitamin D

Indexed as

AgedAlbuminuriaCholecalciferolDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFatty Acids, Omega-3FemaleGlomerular Filtration RateHumansMaleMiddle AgedVitaminsCholecalciferolDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3VitaminsChronic kidney diseaseDiabetesDiabetic kidney diseaseOmega-3 fatty acidsVitamin D

Identifiers

PMID30282055
PMCPMC6203639
OpenAlexW2894779488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.