ArticleCell reports2018
Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 88 citations in OpenAlex.
- An integrated hydrogel-V3 interneuron therapy promotes functional repair of spinal cord injury via neural circuit reconstruction and microenvironment remodeling.Bioactive materials · 2026Article
- Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.Neural regeneration research · 2026Article
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Article
- Rebuilding spinal circuit function after spinal cord injury through a patient-specific interneuron precision model.Frontiers in neuroscience · 2026Article
- Molecularly diverse glycinergic interneurons in the medial deep dorsal horn are interposed between primary sensory afferents and spinal Shox2 interneurons.Frontiers in neural circuits · 2026Article
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.iScience · 2025Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.Cell reports · 2024Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.bioRxiv : the preprint server for biology · 2024Article
- Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- A computational study of how an α- to γ-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An alpha- to gamma-motoneurone collateral can mitigate velocity-dependent stretch reflexes during voluntary movement: A computational study.bioRxiv : the preprint server for biology · 2024Article
- Spinal inhibitory neurons degenerate before motor neurons and excitatory neurons in a mouse model of ALS.Science advances · 2024Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- On the origin of F-wave: involvement of central synaptic mechanisms.Brain : a journal of neurology · 2024Article
- Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.Cell reports · 2024Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- The organization of spinal neurons: Insights from single cell sequencing.Current opinion in neurobiology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Layering of neural circuits facilitates the separation of neurons with high spatial sensitivity from those that play integrative temporal roles. Although anatomical layers are readily identifiable in the brain, layering is not structurally obvious in the spinal cord. But computational studies of motor behaviors have led to the concept of layered processing in the spinal cord. It has been postulated that spinal V3 interneurons (INs) play multiple roles in locomotion, leading us to investigate whether they form layered microcircuits. Using patch-clamp recordings in combination with holographic glutamate uncaging, we demonstrate focal, layered modules, in which ventromedial V3 INs form synapses with one another and with ventrolateral V3 INs, which in turn form synapses with ipsilateral motoneurons. Motoneurons, in turn, provide recurrent excitatory, glutamatergic input to V3 INs. Thus, ventral V3 interneurons form layered microcircuits that could function to ensure well-timed, spatially specific movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.