Evidence map›Paper›PMID 30282016›Full record

ArticleStructure (London, England : 1993)2018

Virus Assembly Antagonists from Redesigned Antibodies.

Zhongchao Zhao, Adam Zlotnick

Open access · bronzeAbstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zhongchao ZhaoDepartment of Molecular and Cellular Biochemistry Indiana University, Bloomington, IN 47405, USA.
Adam ZlotnickDepartment of Molecular and Cellular Biochemistry Indiana University, Bloomington, IN 47405, USA. Electronic address: azlotnic@indiana.edu.
Indiana University Bloomington · US

Funding

Multimode Observation of Virus Capsid AssemblyR01AI118933 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI Adam Zlotnick · 2016 to 2026
$4.0M
NIAID NIH HHS R01 AI118933
6 · The paper itself

Abstract

There is no reliable cure for chronic Hepatitis B Virus (HBV). In this issue of Structure, Eren et al. (2018) show how antibody-derived proteins bind different forms of the HBV capsid protein, blocking assembly. This interaction may also affect downstream signaling. These antibody-derived molecules mark a new strategy that may ultimately contribute to a cure.

Indexed as

Hepatitis B virusVirus AssemblyAntigen-Antibody ComplexCapsidCapsid ProteinsAntigen-Antibody ComplexCapsid Proteins

Identifiers

PMID30282016
PMCPMC12220928
OpenAlexW2894748764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.