ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
A novel patient-specific three-dimensional drug delivery construct for regenerative endodontics.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Optimizing methods for regenerative endodontics.Regenerative medicine · 2025Review
- Local drug delivery for regeneration and disinfection in endodontics: A narrative review.Journal of conservative dentistry and endodontics · 2025Review
- Review
- The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review.Frontiers in dental medicine · 2025Review
- Antimicrobial Silk Fibroin Methacrylated Scaffolds for Regenerative Endodontics.Journal of endodontics · 2024Article
- Tissue engineering approaches for dental pulp regeneration: The development of novel bioactive materials using pharmacological epigenetic inhibitors.Bioactive materials · 2024Review
- Recent advances in additive manufacturing of patient-specific devices for dental and maxillofacial rehabilitation.Dental materials : official publication of the Academy of Dental Materials · 2024Review
- Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.Bioactive materials · 2023Article
- Multifunctional and biodegradable methacrylated gelatin/Aloe vera nanofibers for endodontic disinfection and immunomodulation.Biomaterials advances · 2023Article
- Efficacy of propolis and triple antibiotic paste as intra-canal medicaments for revascularisation of immature teeth in dogs: a comparative study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
- Gelatin methacryloyl hydrogel as an injectable scaffold with multi-therapeutic effects to promote antimicrobial disinfection and angiogenesis for regenerative endodontics.Journal of materials chemistry. B · 2023Article
- Clinical observation of autologous platelet rich fibrin assisted revascularization of mature permanent teeth.Head & face medicine · 2023Article
- Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents.Frontiers in bioengineering and biotechnology · 2023Review
- Natural monoterpenes-laden electrospun fibrous scaffolds for endodontic infection eradication.Odontology · 2023Article
- Regeneration of the Pulp Tissue: Cell Homing versus Cell Transplantation Approach: A Systematic Review.Materials (Basel, Switzerland) · 2022Review
- Expert consensus on regenerative endodontic procedures.International journal of oral science · 2022Review
- Electrospun Azithromycin-Laden Gelatin Methacryloyl Fibers for Endodontic Infection Control.International journal of molecular sciences · 2022Article
- A review on biodegradable biliary stents: materials and future trends.Bioactive materials · 2022Review
- Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Engineering of Injectable Antibiotic-laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Evoked bleeding (EB) clinical procedure, comprising a disinfection step followed by periapical tissue laceration to induce the ingrowth of undifferentiated stem cells from the periodontal ligament and alveolar bone, is currently the only regenerative-based therapeutic approach to treating pulp tissue necrosis in undeveloped (immature) permanent teeth approved in the United States. Yet, the disinfection step using antibiotic-based pastes leads to cytotoxic, warranting a biocompatible strategy to promote root canal disinfection with no or minimal side-effects to maximize the regenerative outcomes. The purpose of this investigation was to develop a tubular three-dimensional (3D) triple antibiotic-eluting construct for intracanal drug delivery. Morphological (scanning electron microscopy), chemical (Fourier transform infrared spectroscopy), and mechanical (tensile testing) characteristics of the polydioxanone-based triple antibiotic-eluting fibers were assessed. The antimicrobial properties of the tubular 3D constructs were determined in vitro and in vivo using an infected (Actinomyces naeslundii) dentin tooth slice model and a canine method of periapical disease, respectively. The in vitro data indicated significant antimicrobial activity and the ability to eliminate bacterial biofilm inside dentinal tubules. In vivo histological findings demonstrated that, using the EB procedure, the tubular 3D triple antibiotic-eluting construct allowed the formation of an appropriate environment that led to apex closure and the ingrowth of a thin layer of osteodentin-like tissue into the root canal. Taken together, these findings indicate that our novel drug delivery construct is a promising biocompatible disinfection strategy for immature permanent teeth with necrotic pulps. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1576-1586, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.