ArticleCancer science2018
Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.
Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity.Communications biology · 2025Article
- Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity.ArXiv · 2025Article
- Tissue geometry and mechanochemical feedback initiate rotational migration inbioRxiv : the preprint server for biology · 2025Article
- Mechanochemical dynamics of collective cells and hierarchical topological defects in multicellular lumens.Science advances · 2024Article
- Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.Development (Cambridge, England) · 2023Article
- Live imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated.Scientific reports · 2022Article
- Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis.BMC biology · 2021Article
- Above the Matrix: Functional Roles for Apically Localized Integrins.Frontiers in cell and developmental biology · 2021Review
- Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers.Cancer science · 2019Article
- ERK Activity Imaging During Migration of Living Cells In Vitro and In Vivo.International journal of molecular sciences · 2019Review
- Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.Cancer science · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
At the invasive front of adenocarcinomas, single cells and multicellular structures exist; the latter include glands and cell clusters, such as tumor buddings and poorly differentiated clusters. Recent reports suggest the importance of collective cell migration in metastasis; however, it is technically difficult to observe the movement of multicellular structures in vivo. We utilized MDCK cells as a model for epithelial cells and established a method to quantify their motility in 3D structures in vitro. A single MDCK cell grows as a cell cluster in the gel and later proliferates and forms a cyst. Active K-RAS expression induced rotation of both the cell clusters and the cysts. The rotation speed of cell clusters was 4 times higher than that of cysts. The screening of inhibitors for their effects on cell clusters and cysts revealed that cyclin B1 and β-catenin were the key molecules for their rotation, respectively. Regulators for cyst rotation, such as vorinostat and β-catenin, were not effective for inducing cell cluster rotation. These results indicate that the signaling pathways of cell dynamics are different between cell clusters and cysts. As cell clusters are related to lymph node involvement and the prognosis of various carcinomas, our in vitro quantitative system may be useful for the screening of drugs to prevent lymphatic invasion.
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Registered trials
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