ArticleCancer science2018
Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05934058 (Interaction of Genomic and Dietary Aspects in Gastric Cancer Risk), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interaction of Genomic and Dietary Aspects in Gastric Cancer Risk: the Global StoP Project
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Pooled it
- Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development.Frontiers in genetics · 2022Pooled it
- Article
- Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells.Stem cell reports · 2026Article
- ABO gene polymorphisms: a molecular bridge linking disease susceptibility to therapeutic outcomes.Frontiers in medicine · 2026Review
- Genetic architecture of gastric adenocarcinoma in West Asia.Clinical and translational medicine · 2025Article
- Prediction of genomic biomarkers for endometriosis using the transcriptomic dataset.World journal of clinical cases · 2025Article
- Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Single-cell eQTL mapping reveals cell-type-specific genes associated with the risk of gastric cancer.Cell genomics · 2025Article
- Leveraging genome-wide association studies to better understand the etiology of cancers.Cancer science · 2025Review
- HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer.Cancer research · 2024Article
- The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.Oncogene · 2023Article
- Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer.BMC medical genomics · 2023Article
- LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.Journal of experimental & clinical cancer research : CR · 2023Article
- Article
- Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes.The Lancet. Oncology · 2023Article
- Evolutionary Origins of Metabolic Reprogramming in Cancer.International journal of molecular sciences · 2022Review
- A statistical physics approach for disease module detection.Genome research · 2022Article
- Incorporating family disease history and controlling case-control imbalance for population-based genetic association studies.Bioinformatics (Oxford, England) · 2022Article
- Silencing of immunoglobulin superfamily containing leucine-rich repeat inhibits gastric cancer cell growth and metastasis by regulating epithelial-mesenchymal transition.Bioengineered · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 16 institutions in 3 countries.
Chizu TanikawaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Osamu ToyoshimaGastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Hiromi SakamotoDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Hidemi ItoDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Aichi, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Takako Takai-IgarashiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Makoto SasakiIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Norie SawadaDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9936-1476
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Mariko NaitoDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
Asahi HishidaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
Norihiro FurusyoDepartment of Environmental Medicine and Infectious Disease, Kyushu University, Fukuoka, Japan.
Yoshinori MurakamiDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yusuke NakamuraDepartments of Medicine and Surgery and Center for Personalized Therapeutics, The University of Chicago, Chicago, USA.
Issei ImotoDepartment of Human Genetics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.ORCID http://orcid.org/0000-0002-4150-7938
Johji InazawaDepartment of Molecular Cytogenetics, Medical Research Institute and Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3945-2800
Isao OzeDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Aichi, Japan.ORCID http://orcid.org/0000-0002-0762-1147
Naomi SatoDepartment of Clinical Nursing, Hamamatsu University School of Medicine, Shizuoka, Japan.
Fumihiko TaniokaDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Haruhiko SugimuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Shizuoka, Japan.ORCID http://orcid.org/0000-0002-0779-3088
Hiroshi HiroseHealth Center, Keio University, Tokyo, Japan.
Teruhiko YoshidaDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Keitaro MatsuoDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Aichi, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Koichi MatsudaLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Aichi Cancer Center · JPHuman Genome Sciences (United States) · USNational Center for Global Health and Medicine · JPRIKEN Center for Integrative Medical Sciences · JPShizuoka University · JPIwate Medical University · JPNagoya University · JPNational Cancer Centre Japan · JPTohoku University · JPHiroshima University · JPKeio University · JPKyushu University · JPNational Cerebral and Cardiovascular Center · JPTokyo Medical and Dental University · JPTokyo Medical University · JPUniversity of Chicago · US
Funding
Grant-in-Aid for Cancer ResearchJapan Agency for Medical Research and DevelopmentJapan Society for the Promotion of Science 15K08792Japan Society for the Promotion of Science 25293168Ministry of Education, Culture, Sports, Science and Technology 16H06277Ministry of Education, Culture, Sports, Science and Technology 17015018Ministry of Education, Culture, Sports, Science and Technology 221S0001Ministry of Health, Labour and WelfareNational Cancer Research and Development Fund
Abstract
Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, herein, we carried out a large-scale genome-wide association study using 6171 cases and 27 178 controls followed by three replication analyses. Analysis using a total of 11 507 cases and 38 904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3.20 × 10
Indexed as
Polymorphism, Single NucleotideABO Blood-Group SystemAdultAgedAged, 80 and overbeta-DefensinsCase-Control StudiesChromosomes, Human, Pair 12Chromosomes, Human, Pair 20Chromosomes, Human, Pair 9FemaleGene Expression RegulationGenetic Predisposition to DiseaseGenome-Wide Association StudyHelicobacter InfectionsHomeodomain ProteinsABO Blood-Group Systembeta-DefensinsHomeodomain ProteinsABOCUX2DEFBgastric cancergenome-wide association study
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What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT05934058ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.