Evidence map›Paper›PMID 30281820›Full record

ArticleAmerican journal of primatology2018

Opportunities and challenges for intranasal oxytocin treatment studies in nonhuman primates.

Melissa D Bauman, Takeshi Murai, Casey E Hogrefe, Michael L Platt

Abstract read
In one paragraph

Article in American journal of primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  8. LeuScientific reports · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Melissa D BaumanDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, California.ORCID 0000-0003-0701-3851
Takeshi MuraiCalifornia National Primate Research Center, University of California, Davis, California.
Casey E HogrefeCalifornia National Primate Research Center, University of California, Davis, California.
Michael L PlattDepartments of Neuroscience, Psychology, and Marketing, University of Pennsylvania, Philadelphia, Pennsylvania.
University of California, Davis · USSumitomo Dainippon Pharma (Japan) · JPUniversity of Pennsylvania · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Pre-clinical evaluation of oxytocin for ASD treatment discoveryR21HD080498 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMAN, MELISSA DAWN, MACHADO, CHRISTOPHER J · 2015 to 2016
$441k
NICHD NIH HHS R21 HD080498NIH HHS P51 OD011107
6 · The paper itself

Abstract

Nonhuman primates provide a human-relevant experimental model system to explore the mechanisms by which oxytocin (OT) regulates social processing and inform its clinical applications. Here, we highlight contributions of the nonhuman primate model to our understanding of OT treatment and address unique challenges in administering OT to awake behaving primates. Prior preclinical research utilizing macaque monkeys has demonstrated that OT can modulate perception of other individuals and their expressions, attention to others, imitation, vigilance to social threats, and prosocial decisions. We further describe ongoing efforts to develop an OT delivery system for use in experimentally naïve juvenile macaque monkeys compatible with naturalistic social behavior outcomes. Finally, we discuss future directions to further develop the rhesus monkey as a preclinical test bed to evaluate the effects of OT exposure and advance efforts to translate basic science OT research into safe and effective OT therapies.

Indexed as

Macaca mulattaAdministration, IntranasalAnimalsFemaleMaleOxytocinSocial BehaviorOxytocindeliveryoxytocinrhesus

Identifiers

PMID30281820
PMCPMC6690341
OpenAlexW2894718901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.