ArticleAIDS (London, England)2018
Living donor liver transplant from an HIV-positive mother to her HIV-negative child: opening up new therapeutic options.
Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Donor-derived viral infections: the usual suspects and the new kids on the block.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Solid organ transplantation in people with HIV: Outcomes, obstacles and opportunities.HIV medicine · 2025Review
- Evaluating Challenges in Access To Transplantation for Persons with HIV.Current HIV/AIDS reports · 2025Review
- The changing landscape of HIV-associated kidney disease.Nature reviews. Nephrology · 2024Review
- Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Inner Workings: Advances in infectious disease treatment promise to expand the pool of donor organs.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Assessing Global Organ Donation Policies: Opt-In vs Opt-Out.Risk management and healthcare policy · 2021Review
- Update on liver transplantation-newer aspectsTurkish journal of medical sciences · 2020Review
- Organ transplantation in persons with HIV.AIDS (London, England) · 2020Review
- Southern African HIV Clinicians Society guidelines for solid organ transplantation in human immunodeficiency virus: An evidence-based framework for human immunodeficiency virus-positive donors and recipients.Southern African journal of HIV medicine · 2020Article
- Expanding the donor pool: Hepatitis C, hepatitis B and human immunodeficiency virus-positive donors in liver transplantation.World journal of gastroenterology · 2019Review
- HIV and Solid Organ Transplantation: Where Are we Now.Current HIV/AIDS reports · 2019Review
- Needs must: living donor liver transplantation from an HIV-positive mother to her HIV-negative child in Johannesburg, South Africa.Journal of medical ethics · 2019Article
- Challenges in solid organ transplantation in people living with HIV.Intensive care medicine · 2019Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTransplant a liver from an HIV-positive mother to her HIV-negative child to save the child's life.
designA unique case of living donor liver transplantation from an HIV-positive mother to her HIV-negative child in South Africa. Two aspects of this case are ground-breaking. First, it involves living donation by someone who is HIV-positive and second it involves controlled transplant of an organ from an HIV-positive donor into an HIV-negative recipient, with the potential to prevent infection in the recipient.
methodsStandard surgical procedure for living donor liver transplantation at our centre was followed. HIV-prophylaxis was administered preoperatively. Extensive, ultrasensitive HIV testing, over and above standard diagnostic assays, was undertaken to investigate recipient serostatus and is ongoing.
resultsBoth mother and child are well, over 1 year posttransplantation. HIV seroconversion in our recipient was detected with serological testing at day 43 posttransplant. However, a decline in HIV antibody titres approaching undetectable levels is now being observed. No plasma, or cell-associated HIV-1 DNA has been detected in the recipient at any time-point since transplant.
conclusionThis case potentially opens up a new living liver donor pool which might have clinical relevance in countries where there is a high burden of HIV and a limited number of deceased donor organs or limited access to transplantation. However, our recipient's HIV status is equivocal at present and additional investigation regarding seroconversion events in this unique profile is ongoing.
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