Evidence map›Paper›PMID 30281394›Full record

ArticleMolecular biology of the cell2018

Depletion of SMC5/6 sensitizes male germ cells to DNA damage.

G Hwang, D E Verver, M A Handel, G Hamer, P W Jordan

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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  6. International journal of molecular sciences · 2023
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  12. Whole genome sequencing identifies allelic ratio distortion in sperm involving genes related to spermatogenesis in a swine model.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

G HwangDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
D E VerverReproductive Biology Laboratory, Center for Reproductive Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
M A HandelThe Jackson Laboratory, Bar Harbor, ME 04609.
G HamerReproductive Biology Laboratory, Center for Reproductive Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
P W JordanDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Amsterdam UMC Location University of Amsterdam · NLJohns Hopkins University · USJackson Laboratory · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Anna Karolina Palucka · 1985 to 2026
$61.9M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
CELL CYCLE REGULATION DURING SPERMATOGENESISR01HD033816 · NICHD · UNIVERSITY OF TENNESSEE KNOXVILLE · PI HANDEL, MARY ANN · 1996 to 2016
$4.7M
Regulation of microtubule organizing centers during mammalian gametogenesisR01GM117155 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Philip W Jordan · 2016 to 2026
$4.3M
The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic FidelityR00HD069458 · NICHD · JOHNS HOPKINS UNIVERSITY · PI JORDAN, PHILIP W · 2013 to 2015
$613k
The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic FidelityK99HD069458 · NICHD · JACKSON LABORATORY · PI JORDAN, PHILIP W · 2011 to 2012
$180k
NCI NIH HHS P30 CA034196NCI NIH HHS T32 CA009110NICHD NIH HHS K99 HD069458NICHD NIH HHS R00 HD069458NICHD NIH HHS R01 HD033816NIGMS NIH HHS R01 GM117155
6 · The paper itself

Abstract

The structural maintenance of chromosomes complex SMC5/6 is thought to be essential for DNA repair and chromosome segregation during mitosis and meiosis. To determine the requirements of the SMC5/6 complex during mouse spermatogenesis we combined a conditional knockout allele for

Indexed as

DNA DamageAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsDEAD-box RNA HelicasesDNA ReplicationEtoposideFemaleMaleMeiosisMiceMice, KnockoutPachytene StageSpermatocytesSpermatogenesisTestisAdaptor Proteins, Signal TransducingCell Cycle ProteinsDdx4 protein, mouseDEAD-box RNA HelicasesEtoposideSMC5 protein, mouseSMC6 protein, mouseStra8 protein, mouse

Identifiers

PMID30281394
PMCPMC6333175
OpenAlexW2894673025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.