ArticleMolecular biology of the cell2018
Application of the fluctuation theorem for noninvasive force measurement in living neuronal axons.
Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nanometer-resolution tracking of single cargo reveals dynein motor mechanisms.Nature chemical biology · 2025Article
- Multiple kinesins speed up cargo transport in crowded environments by sharing load.Communications biology · 2025Article
- Nonthermal fluctuations accelerate biomolecular motors.Biophysical reviews · 2024Review
- The third Japan-U.S. symposium on motor proteins and associated single-molecule biophysics.Biophysics and physicobiology · 2023Article
- Effects of dynein inhibitor on the number of motor proteins transporting synaptic cargos.Biophysical journal · 2021Article
- Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms.The Journal of cell biology · 2021Article
- Physical parameters describing neuronal cargo transport by kinesin UNC-104.Biophysical reviews · 2019Review
- Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ.Scientific reports · 2019Article
- Application of the fluctuation theorem to motor proteins: from FBiophysical reviews · 2018Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although its importance is recently widely accepted, force measurement has been difficult in living biological systems, mainly due to the lack of the versatile noninvasive force measurement methods. The fluctuation theorem, which represents the thermodynamic properties of small fluctuating nonequilibrium systems, has been applied to the analysis of the thermodynamic properties of motor proteins in vitro. Here we extend it to the axonal transport (displacement) of endosomes. The distribution of the displacement fluctuation had three or four distinct peaks around multiples of a unit value, which the fluctuation theorem can convert into the drag force exerted on the endosomes. The results demonstrated that a single cargo vesicle is conveyed by one to three or four units of force production.
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