Evidence map›Paper›PMID 30281370›Full record

ReviewArchives of pathology & laboratory medicine2018

Atypical Ductal Lesions of the Breast: Criteria, Significance, and Laboratory Updates.

Ellen G East, Cody S Carter, Celina G Kleer

Open access · diamondAbstract readReview
In one paragraph

Review in Archives of pathology & laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Active Monitoring versus Surgical Excision for Atypical Ductal Hyperplasia.Cancer prevention research (Philadelphia, Pa.) · 2026
    Observational
  2. A Multicentre Observational Study on Risk Factors for Breast Cancer.Journal of obstetrics and gynaecology of India · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen G EastFrom the Department of Pathology, Michigan Medicine, University of Michigan Rogel Cancer Center, Ann Arbor.
Cody S CarterFrom the Department of Pathology, Michigan Medicine, University of Michigan Rogel Cancer Center, Ann Arbor.
Celina G KleerFrom the Department of Pathology, Michigan Medicine, University of Michigan Rogel Cancer Center, Ann Arbor.
Michigan Medicine · US

Funding

Role of EZH2 in Breast Cancer ProgressionR01CA107469 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Celina G Kleer · 2005 to 2026
$5.9M
Role of CCN6 (WISP3) in the Progression and Metastasis of Breast Cancer.R01CA125577 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Celina G Kleer · 2008 to 2026
$5.5M
NCI NIH HHS R01 CA107469NCI NIH HHS R01 CA125577
6 · The paper itself

Abstract

CONTEXT.—: Atypical ductal hyperplasia (ADH) is a challenging diagnosis defined by cytologic and architectural features that carries an increased risk of subsequent carcinoma when diagnosed in isolation. In addition, ADH may secondarily involve benign breast lesions, wherein it carries variable clinical significance. OBJECTIVES.—: To review the diagnostic criteria and clinical significance of ADH in isolation and as it involves benign breast lesions, and to review the evolving literature on its molecular signature. DATA SOURCES.—: Recently published studies that collectively examine ADH were reviewed. CONCLUSIONS.—: Atypical ductal hyperplasia carries an increased risk of subsequent carcinoma in isolation and when it involves most benign breast lesions. Identifying which cases of ADH will be upgraded to carcinoma has been challenging, and new laboratory developments, such as EZH2 overexpression, may have a future role.

Indexed as

Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleHumans

Identifiers

PMID30281370
PMCPMC12900281
OpenAlexW2894863604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.