ArticleeLife2018
Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
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Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Bid Protein: A Participant in the Apoptotic Network with Roles in Viral Infections.International journal of molecular sciences · 2025Review
- Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology.Frontiers in physiology · 2025Review
- Mitochondrial Structure and Function in Human Heart Failure.Circulation research · 2024Review
- Transcriptome-Wide Association Studies (TWAS): Methodologies, Applications, and Challenges.Current protocols · 2024Article
- Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology.Antioxidants & redox signaling · 2023Review
- Apoptotic mitochondrial poration by a growing list of pore-forming BCL-2 family proteins.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma.Frontiers in oncology · 2023Article
- Promotion of diet-induced obesity and metabolic syndromes by BID is associated with gut microbiota.Hepatology communications · 2022Article
- Revealing the Impact of Mitochondrial Fitness During Early Neural Development Using Human Brain Organoids.Frontiers in molecular neuroscience · 2022Review
- Mitochondrial Function and Microbial Metabolites as Central Regulators of Intestinal Immune Responses and Cancer.Frontiers in microbiology · 2022Article
- Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome.Stem cell research · 2021Article
- Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Review
- Geniposide fromDrug design, development and therapy · 2021Article
- Review
- Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway.International journal of molecular sciences · 2020Article
- A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate.International review of cell and molecular biology · 2020Review
- Remodeling of mitochondrial morphology and function: an emerging hallmark of cellular reprogramming.Cell stress · 2019Review
- Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation.Cell cycle (Georgetown, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 3 countries.
Christi T Salisbury-Ruf *Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Clinton C Bertram *Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Aurelia VergeadeDepartment of Pharmacology, Vanderbilt University, Nashville, United States.
Daniel S LarkMolecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Qiong ShiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Marlene L HeberlingDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.
Niki L FortuneDepartment of Medicine, Vanderbilt University Medical Center, Nashville, United States.
G Donald OkoyeDivision of Cardiovascular Medicine and Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, United States.ORCID http://orcid.org/0000-0003-1078-688X
W Gray JeromeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.
Quinn S WellsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Josh FesselDepartment of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Javid MoslehiDivision of Cardiovascular Medicine and Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, United States.
Heidi ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, United States.
L Jackson RobertsDepartment of Pharmacology, Vanderbilt University, Nashville, United States.
Olivier BoutaudDepartment of Pharmacology, Vanderbilt University, Nashville, United States.
Eric R GamazonDivision of Genetic Medicine, Vanderbilt University Medical Center, Nashville, United States.
Sandra S ZinkelDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.ORCID http://orcid.org/0000-0002-2818-9795
Vanderbilt University · USVanderbilt University Medical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Cambridge · GB
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6MTHE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1985 to 2010
$15.0MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MTherapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MHarnessing GTEx to Create Transcriptome Knowledge and Inform Disease BiologyR01MH101820 · NIMH · UNIVERSITY OF CHICAGO · PI COX, NANCY J, NICOLAE, DAN LIVIU · 2013 to 2015
$2.3MPro-apoptotic BID in DNA Damage and LeukemogenesisR01HL088347 · NHLBI · VANDERBILT UNIVERSITY · PI ZINKEL, SANDRA S · 2007 to 2011
$2.1MMechanisms of necrosis regulation of hematopoietic stem cell functionR01HL133559 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZINKEL, SANDRA S · 2018 to 2021
$1.6MUsing the Transcriptome for SNP and Gene AnnotationR01MH090937 · NIMH · UNIVERSITY OF CHICAGO · PI COX, NANCY J, NICOLAE, DAN LIVIU · 2010 to 2012
$825kBLRD VA I01 BX002250NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NHLBI NIH HHS 1R01HL088347NHLBI NIH HHS 1 R01HL133559NHLBI NIH HHS K08 HL121174NHLBI NIH HHS K08HL121174NHLBI NIH HHS R01 HL088347NHLBI NIH HHS R01 HL133559NIDDK NIH HHS GRU2558NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NIGMS NIH HHS 2P01 GM015431NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH101820VA 1I01BX002250
Abstract
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein Bid. Loss of full-length Bid results in apoptosis-independent, irregular cristae with decreased respiration.
Indexed as
GenomicsAnimalsApoptosisBeclin-1BH3 Interacting Domain Death Agonist ProteinCell RespirationFibrosisGene Expression RegulationGenome-Wide Association StudyHeart DiseasesHeart VentriclesHumansMice, Inbred C57BLMitochondriaMitochondrial Proton-Translocating ATPasesMutationBeclin-1BH3 Interacting Domain Death Agonist ProteinMitochondrial Proton-Translocating ATPasesProtein SubunitsReactive Oxygen SpeciesBcl-2 familycell biologycristaeelectronic health recordhumanhuman genetics & genomicsmaizemitochondriamousemyocardial infarction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.