Evidence map›Paper›PMID 30281019›Full record

ArticleeLife2018

Visualization of the type III secretion mediated

Donghyun Park, Maria Lara-Tejero, M Neal Waxham, Wenwei Li, Bo Hu, Jorge E Galán, Jun Liu

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The interplay betweenCell insight · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. A Tale aboutMicroorganisms · 2023
    Review
  19. Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Donghyun ParkDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0003-2048-6004
Maria Lara-TejeroDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.
M Neal WaxhamDepartment of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, United States.
Wenwei LiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.
Bo HuDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, United States.
Jorge E GalánDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0002-6531-0355
Jun LiuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0003-3108-6735

Funding

MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR37AI030492 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2000 to 2024
$10.1M
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR01AI030492 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 1995 to 2026
$3.1M
Structural basis of signaling between bacterial chemoreceptors and flagellaR01GM107629 · NIGMS · YALE UNIVERSITY · PI LIU, JUN · 2014 to 2017
$1.5M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR29AI030492 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI GALAN, JORGE E · 1991 to 1995
–
National Institute of Allergy and Infectious Diseases AI030492NIAID NIH HHS R01 AI030492NIAID NIH HHS R01 AI087946NIAID NIH HHS R37 AI030492NIGMS NIH HHS GM107629NIGMS NIH HHS R01 GM107629
6 · The paper itself

Abstract

Many important gram-negative bacterial pathogens use highly sophisticated type III protein secretion systems (T3SSs) to establish complex host-pathogen interactions. Bacterial-host cell contact triggers the activation of the T3SS and the subsequent insertion of a translocon pore into the target cell membrane, which serves as a conduit for the passage of effector proteins. Therefore the initial interaction between T3SS-bearing bacteria and host cells is the critical step in the deployment of the protein secretion machine, yet this process remains poorly understood. Here, we use high-throughput cryo-electron tomography (cryo-ET) to visualize the T3SS-mediated

Indexed as

Bacterial ProteinsCell MembraneElectron Microscope TomographyHeLa CellsHost-Pathogen InteractionsHumansMutationProtein TransportSalmonella typhimuriumType III Secretion SystemsBacterial ProteinsType III Secretion Systemsbacterial pathogenesishost-pathogen interactioninfectious diseaseMacromolecular assemblymembrane remodelingmicrobiologyprotein secretionS. entericaserovar typhie

Identifiers

PMID30281019
PMCPMC6175578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.