Evidence map›Paper›PMID 30280963›Full record

ArticleStem cells and development2018

Transplanted Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Support Liver Regeneration in Gunn Rats.

Lucas-Sebastian Spitzhorn, Claus Kordes, Matthias Megges, Iris Sawitza, Silke Götze, Doreen Reichert, Peggy Schulze-Matz, Nina Graffmann, Martina Bohndorf, Wasco Wruck and 6 more

Open access · greenAbstract read
In one paragraph

Article in Stem cells and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  3. Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Lucas-Sebastian SpitzhornInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Claus KordesClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Matthias MeggesInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Iris SawitzaClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Silke GötzeClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Doreen ReichertClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Peggy Schulze-MatzInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Nina GraffmannInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Martina BohndorfInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Wasco WruckInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Jan Philipp KöhlerClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Diran HerebianDepartment of General Pediatrics, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Ertan MayatepekDepartment of General Pediatrics, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Richard O C OreffoCentre for Human Development, Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Dieter HäussingerClinic of Gastroenterology, Hepatology and Infectious Diseases, and Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
James AdjayeInstitute for Stem Cell Research and Regenerative Medicine, Neonatolgy and Pediatric Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Southampton · GB

Funding

ResourceP40OD011062 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Elizabeth C Bryda · 2012 to 2026
$24.0M
Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/K026682/1NIH HHS P40 OD011062
6 · The paper itself

Abstract

Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (

Indexed as

Liver RegenerationAlbuminsAnimalsATP-Binding Cassette TransportersCell DifferentiationCells, CulturedHepatocyte Nuclear Factor 4HepatocytesHumansKeratin-18Liver DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOrganic Anion Transporters, Sodium-DependentPluripotent Stem CellsRatsAbcc2 protein, ratAlbuminsATP-Binding Cassette TransportersHepatocyte Nuclear Factor 4Keratin-18Organic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportersESCfetal MSCiMSCiPSCliver regenerationstem cell transplantation

Identifiers

PMID30280963
PMCPMC7366275
OpenAlexW2894970744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.