Evidence map›Paper›PMID 30280905›Full record

ArticleAIDS research and human retroviruses2019

Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury.

Vatsalya Vatsalya, Matthew C Cave, Rajarshi Kumar, Shweta Srivastava, Sujita Khanal, Alfred B Jenson, Melanie L Schwandt, Shirish S Barve, Vijay A Ramchandani, Craig J McClain

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Alcohol use disorder research in India: An update.Indian journal of psychiatry · 2024
    Review
  2. Article
  3. Review
  4. Review
  5. Dysregulation in PlasmaAdvances in virology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vatsalya Vatsalya1 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
Matthew C Cave1 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
Rajarshi Kumar7 Calcutta National Medical College and Hospital, West Bengal University of Health Sciences, Calcutta, India.
Shweta Srivastava8 Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
Sujita Khanal9 Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky.
Alfred B Jenson9 Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky.
Melanie L Schwandt10 Office of Clinical Director, NIAAA, National Institutes of Health, Bethesda, Maryland.
Shirish S Barve1 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
Vijay A Ramchandani2 Section on Human Psychopharmacology, DICBR/NIAAA, National Institutes of Health, Bethesda, Maryland.
Craig J McClain1 Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky.
University of Louisville · USLouisville VA Medical Center · US

Funding

Alcohol Pharmacokinetics and Pharmacodynamics in HumansZIAAA000466 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI RAMCHANDANI, VIJAY ARJUN · 2009 to 2025
$31.2M
Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Novel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0M
Role of Gut Microbial Dysbiosis and Aging on HIV-associated neurocognitive and brain dysfunctionR01AG061065 · NIA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S, COHEN, RONALD A · 2018 to 2022
$3.8M
1/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV)U01AA026222 · NIAAA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARVE, SHIRISH S, FREIBERG, MATTHEW S · 2017 to 2021
$3.4M
Administrative Supplement Role of Gut Microbial Dysbiosis in Aging on HIV-associated in the Development of Alzheimer's DiseaseAssociated Dementia (ADRD).U01AA026225 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S, COOK, ROBERT L · 2017 to 2021
$3.4M
Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7M
Role of Gut Microbiome and DHA Deficiency in Alcohol Induced NeuroinflammationU01AA022618 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S · 2016 to 2020
$1.7M
Mechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6M
SAM Deficiency Mediated Epigenetic Mechanisms in Alcohol induced ImmunosuppressionR01AA024405 · NIAAA · UNIVERSITY OF LOUISVILLE · PI BARVE, SHIRISH S · 2015 to 2019
$1.6M
Novel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5M
BLRD VA I01 BX002996Intramural NIH HHS Z01 AA000466Intramural NIH HHS Z99 AA999999NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R01 AA024405NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA021901NIAAA NIH HHS U01 AA022489NIAAA NIH HHS U01 AA022618NIAAA NIH HHS U01 AA026222NIAAA NIH HHS U01 AA026225NIA NIH HHS R01 AG061065NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

Heavy alcohol drinking causes alterations in the metabolism of fatty acids and zinc that participate in inflammation and liver injury. HIV infection has been reported to cause dysregulated polyunsaturated fatty acid (PUFA) and zinc metabolism. In this pilot study, we examined the role of dysregulated PUFA metabolism and zinc deficiency in the liver injury occurring in heavy drinkers with early-stage HIV diagnosis. Fourteen heavy drinking alcohol-dependent (AD) patients [seven with treatment-naive HIV diagnosis (AD+HIV) and seven without HIV infection (AD)] participated in this study. Liver injury, serum zinc, PUFAs, viral load, CD4

Indexed as

AdultAgedAlcoholismChemical and Drug Induced Liver InjuryFatty Acids, UnsaturatedFemaleHIV InfectionsHumansMaleMiddle AgedPilot ProjectsSerumYoung AdultZincFatty Acids, UnsaturatedZincalcohol dependentCD4HIVliver injuryPUFAsserum zinc

Identifiers

PMID30280905
PMCPMC6343188
OpenAlexW2895440914

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.