Evidence map›Paper›PMID 30280586›Full record

Trial reportCartilage2020

Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee.

Matthew T Wolf, Hong Zhang, Blanka Sharma, Norman A Marcus, Uwe Pietzner, Stefan Fickert, Achim Lueth, G H Robert Albers, Jennifer H Elisseeff

Abstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Prognostic factors for the management of chondral defects of the knee and ankle joint: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Pooled it
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  6. A bioactive supramolecular and covalent polymer scaffold for cartilage repair in a sheep model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. [Advances in clinical repair techniques for localized knee cartilage lesions].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
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  17. Microbial Transglutaminase ImprovesFrontiers in medical technology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew T WolfTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0328-2475
Hong ZhangTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Blanka SharmaJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Norman A MarcusVirginia Cartilage Institute, Springfield, VA, USA.
Uwe PietznerDepartment of Arthroscopic Surgery and Sport Traumatology, Clinic for Orthopedics and Trauma Surgery, Dietrich-Bonhoeffer-Klinikum Neubrandenburg, Altentreptow, Germany.
Stefan FickertSporthopaedicum Straubing Berlin Regensburg, Straubing, Germany.
Achim LuethPraxisclinic Zaehringen, Department of Orthopedics, Freiburg, Germany.
G H Robert AlbersAVE Orthopedic Clinics, Huizen, Netherlands.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Statistical optimization of self-assembled biosynthetic cornea implantsR01EY029055 · NEI · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2018 to 2021
$1.8M
NEI NIH HHS R01 EY029055
6 · The paper itself

Abstract

objectiveTo determine performance and repair kinetics of the ChonDux hydrogel scaffold for treating focal articular cartilage defects in the knee over 24 months.

designThis assessor-blinded trial evaluates ChonDux hydrogel scaffold implantation in combination with microfracture in 18 patients across 6 sites. Male and female patients 18 to 65 years of age with full-thickness femoral condyle defects 2 to 4 cm

resultsChonDux maintained durable tissue restoration over 24 months with final defect percent fill of 94.2% ± 16.3% and no significant loss of fill volume at any time points. Tissues treated with ChonDux maintained T2 relaxation times similar to uninjured cartilage between 12 and 24 months. VAS pain scoring decreased between 1 and 6 weeks, and IKDC knee function scores improved by approximately 30.1 with ChonDux over 24 months.

conclusionChonDux treatment is a safe adjunct to microfracture therapy and promotes stable restoration of full thickness articular cartilage defects for at least 24 months.

Indexed as

AdolescentAdultAgedCartilage, ArticularCartilage DiseasesCombined Modality TherapyDisability EvaluationFemaleFemurFollow-Up StudiesFractures, StressHumansHydrogelsKineticsKnee InjuriesKnee JointHydrogelsbiomaterialscartilage repairmicrofracturescaffoldtissue engineering

Identifiers

PMID30280586
PMCPMC7488951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.