Trial reportAddiction (Abingdon, England)2019
A developmental cascade model for early adolescent-onset substance use: the role of early childhood stress.
Trial report in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use.Development and psychopathology · 2022Trial
- A developmental cascade model for early adolescent-onset substance use: the role of early childhood stress.Addiction (Abingdon, England) · 2019Trial
- Substance use involvement moderates the effect of cortisol response on white-matter microstructure longitudinally.Dialogues in clinical neuroscience · 2026Article
- The Utility of Machine Learning-Enhanced Developmental Cascade Models in Prevention Science.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Violence and threat exposure is associated with frontostriatal alterations during risky decision-making in children with co-morbid ADHD and disruptive behavior disorders.Frontiers in psychiatry · 2026Article
- Exercise as a Promising Adjunct Treatment for Methamphetamine Addiction: Advances in Understanding Neuroplasticity and Clinical Applications.Brain sciences · 2025Review
- Early onset of tobacco use behaviour and maintenance of tobacco abstinence: The impact of tobacco user in family.Journal of family medicine and primary care · 2025Article
- Balancing Relief and Risk: The Potential Impact of Pediatric Opioid Prescriptions on Family Members.The Journal of pediatrics · 2025Article
- Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits.Biomedicines · 2025Review
- Towards a better understanding of inequity and the psychological processes underlying the intergenerational transmission of socioeconomic status.Social science & medicine (1982) · 2024Article
- Pathways to substance use: Examining conduct problems and parenting behaviors from preschool to adolescence.Development and psychopathology · 2024Article
- Understanding the shift to compulsion in addiction: insights from personality traits, social factors, and neurobiology.Frontiers in psychology · 2024Review
- Predictors of problematic adult alcohol, cannabis, and other substance use: A longitudinal study of two samples.Development and psychopathology · 2023Article
- The mediating role of self-regulation on the link between child maltreatment and later substance use among Latinx youth.Child abuse & neglect · 2023Article
- A gene-environment cascade theoretical framework of developmental psychopathology.Journal of psychopathology and clinical science · 2023Article
- Associations between early childhood adversity and behavioral, substance use, and academic outcomes in childhood through adolescence in a U.S. longitudinal cohort.Drug and alcohol dependence · 2023Article
- Article
- Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study.Development and psychopathology · 2022Article
- The joint development of externalizing and internalizing behaviors in black and Hispanic youth and the link to late adolescent substance use.Development and psychopathology · 2022Article
- Developmental cascades in studies of adolescent and young adult substance use etiology: A systematic review.Addictive behaviors reports · 2022Review
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUNDS AND
aimsDespite the link between stress and addictive behavior in adulthood, little is known about how early life stress in families predicts the early emergence of substance use in adolescence. This study tested a developmental cascade model, proposing that early stressful life events and negative parent-child interaction covary, and both disrupt the refinement of inhibitory control, which evolves into problem behavior in middle/late childhood and subsequent substance use exploration in early adolescence.
methodsData came from the Early Steps Multisite study, a community sample of at-risk families in the metropolitan US areas of Pittsburgh (Pennsylvania), Eugene (Oregon) and Charlottesville (Virginia) with children aged 2 years at the start of the study and 14 years at the last measurement (n = 364). Structural equation modeling was used to test the proposed model.
resultsEarly stressful life events and negative parent-child interaction assessed at ages 2-5 were negatively related to inhibitory control at ages 7 and 8. Low levels of inhibitory control were prognostic of childhood problem behavior at ages 9 and 10. Finally, late childhood problem behavior was associated with substance use at age 14. Parental drug use was directly related to substance use at age 14.
conclusionsEarly life stress may disrupt child inhibitory control, which can cascade into behavioral and peer problem behavior in childhood and, in turn, heighten the risk for early adolescent substance use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.