ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2019
Monitoring Early Breast Cancer Response to Neoadjuvant Therapy Using H-Scan Ultrasound Imaging: Preliminary Preclinical Results.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Assessment of Early Breast Cancer Response to Chemotherapy with Ultrasound Radiomics.Diagnostics (Basel, Switzerland) · 2026Article
- Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology.Medical & biological engineering & computing · 2025Article
- MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens.NPJ digital medicine · 2025Article
- H-Scan Ultrasound Monitoring of Breast Cancer Response to Chemotherapy and Validation With Diffusion-Weighted Magnetic Resonance Imaging.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023Article
- High-Resolution Ultrasound Characterization of Local Scattering in Cancer Tissue.Ultrasound in medicine & biology · 2023Article
- Generalized mathematical framework for contrast-enhanced ultrasound imaging with pulse inversion spectral deconvolution.Ultrasonics · 2023Article
- Unraveling the Pivotal Network of Ultrasound and Somatic Mutations in Triple-Negative and Non-Triple-Negative Breast Cancer.Breast cancer (Dove Medical Press) · 2023Article
- 3-D H-scan ultrasound imaging of relative scatterer size using a matrix array transducer and sparse random aperture compounding.Computers in biology and medicine · 2022Article
- Research on the Multi-Element Synthetic Aperture Focusing Technique in Breast Ultrasound Imaging, Based on the Ring Array.Micromachines · 2022Article
- MRI-Based Digital Models Forecast Patient-Specific Treatment Responses to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.Cancer research · 2022Article
- Photoacoustic graphic equalization and application in characterization of red blood cell aggregates.Photoacoustics · 2022Article
- Article
- Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers.Scientific reports · 2021Article
- H-scan, Shear Wave and Bioluminescent Assessment of the Progression of Pancreatic Cancer Metastases in the Liver.Ultrasound in medicine & biology · 2020Article
- 3-D H-Scan Ultrasound Imaging and Use of a Convolutional Neural Network for Scatterer Size Estimation.Ultrasound in medicine & biology · 2020Article
- Fine-tuning the H-scan for discriminating changes in tissue scatterers.Biomedical physics & engineering express · 2020Article
- Adaptive attenuation correction during H-scan ultrasound imaging using K-means clustering.Ultrasonics · 2020Article
- Classification of Benign and Malignant Breast Tumors Using H-Scan Ultrasound Imaging.Diagnostics (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveH-scan imaging is a new ultrasound technique used to visualize the relative size of acoustic scatterers. The purpose of this study was to evaluate the use of H-scan ultrasound imaging for monitoring early tumor response to neoadjuvant treatment using a preclinical breast cancer animal model.
methodsReal-time H-scan ultrasound imaging was implemented on a programmable ultrasound scanner (Vantage 256; Verasonics Inc., Kirkland, WA) equipped with an L11-4v transducer. Bioluminescence and H-scan ultrasound was used to image luciferase-positive breast cancer-bearing mice at baseline and at 24, 48, and 168 hours after administration of a single dose of neoadjuvant (paclitaxel) or sham treatment. Animals were euthanized at 48 or 168 hours, and tumors underwent histologic processing to identify cancer cell proliferation and apoptosis.
resultsBaseline H-scan ultrasound images of control and therapy group tumors were comparable, but the latter exhibited significant changes over the 7-day study (P < .05). At termination, there was a marked difference between the H-scan ultrasound images of control and treated tumors (P < .05). Specifically, H-scan ultrasound images of treated tumors were more blue in hue than images obtained from control tumors. There was a significant linear correlation between the predominance of the blue hue found in the H-scan ultrasound images and intratumoral apoptotic activity (R
conclusionPreliminary preclinical results suggest that H-scan ultrasound imaging is a new and promising tissue characterization modality. H-scan ultrasound imaging may provide prognostic value when monitoring early tumor response to neoadjuvant treatment.
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