ArticleEnvironmental science and pollution research international2018
Association of benzene exposure with insulin resistance, SOD, and MDA as markers of oxidative stress in children and adolescents.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.Diabetes · 2024Pooled it
- Systematic review and meta-analysis on the association between phthalates exposure and insulin resistance.Environmental science and pollution research international · 2019Pooled it
- XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance.Endocrine connections · 2026Article
- Comparing Differences in Blood Malondialdehyde and Risk Factors Among Four Occupations Around an Industrial Estate, Rayong Province of Thailand.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Prospective study of oil spill cleanup-related exposure to volatile organic compounds and glycemic dysregulation.Environmental health : a global access science source · 2025Article
- Oil spill cleanup related exposures to benzene, toluene, ethylbenzene, xylenes, and n-hexane and incident diabetes mellitus.Environmental research · 2025Article
- Exposure to Environmental Chemicals from Environmental Tobacco Smoking in Korean Adolescents.Toxics · 2025Article
- Investigating the effects of co-exposure to noise and benzene on serum oxidative stress in rat.Toxicology reports · 2024Article
- Gastrodin prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- FermentedFoods (Basel, Switzerland) · 2024Article
- Metabolomics of Benzene Exposure and Development of Biomarkers for Exposure Hazard Assessment.Metabolites · 2024Article
- Hearing Loss and UrinaryToxics · 2024Article
- Alterations in leukocyte telomere length and mitochondrial DNA copy number in benzene poisoning patients.Molecular biology reports · 2024Article
- The Benzene-induced Hepatic Cytochrome P450 2E1 Expression and Activity are Reduced by Quercetin Administration in Mice.Current pharmaceutical design · 2024Article
- Article
- GGA (geranylgeranylacetone) ameliorates bleomycin-induced lung inflammation and pulmonary fibrosis by inhibiting apoptosis and oxidative stress.Molecular biology reports · 2023Article
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- Association of Short-Term Exposure to PMToxics · 2022Article
- Association of metabolites of benzene and toluene with lipid profiles in Korean adults: Korean National Environmental Health Survey (2015-2017).BMC public health · 2022Article
- The association between oil spill cleanup-related total hydrocarbon exposure and diabetes.Environmental research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Benzene is a ubiquitous environmental pollutant with various health effects. It is reported that benzene exposure might be associated with insulin resistance in elderly adults. The aim of this study is to investigate the association between urinary benzene metabolite, trans, trans-muconic acid (t,t-ma) and markers of oxidative stress and insulin resistance in children and adolescents. This cross-sectional study was conducted in 2017 among 86 children and adolescents, aged 6-18 years, living in Isfahan, Iran. t,t-ma was measured as urinary benzene metabolite and homeostasis model assessment (HOMA-IR) was determined as an index of insulin resistance. Moreover, malondialdehyde (MDA) and superoxide dismutase (SOD) were assessed as oxidative stress markers. We found significant association between insulin resistance, fasting blood glucose, and fasting blood insulin with t,t-ma (p values = 0.002, 0.03, and 0.001, respectively). Results of this study indicate that benzene metabolite in higher concentrations in comparison with lower concentrations is associated with increased risk of insulin resistance. Moreover, after adjustment for age, sex, and household passive smoking, statistically significant increase were documented in SOD and MDA (4.49- and 3.54-fold, respectively) in intermediate levels of t,t-ma vs. low levels of t,t-ma (p values = 0.01 and 0.034, respectively). To the best of our knowledge, this is the first study in its kind in the pediatric age group. It showed that benzene exposures, even in environmental levels, might be associated with insulin resistance and oxidative stress in children and adolescents. Further longitudinal studies are necessary to assess the clinical impacts of this finding.
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