ArticleEuropean radiology experimental2018
Impact of fixation, coil, and number of excitations on diffusion tensor imaging of rat brains at 7.0 T.
Article in European radiology experimental, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Deep learning reconstruction enables accelerated T2-weighted MRI for rectal cancer staging: a prospective study of diagnostic consistency across NEX value reduction.Abdominal radiology (New York) · 2026Article
- Effects of perfusion fixation on whole-brain structural connectivity in marmoset: a diffusion MRI analysis.Radiological physics and technology · 2026Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- Relationship between regional volume changes and water diffusion in fixed marmoset brains: an in vivo and ex vivo comparison.Scientific reports · 2024Article
- Mean Kärger Model Water Exchange Rate in Brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- The orbitofrontal cortex of the sheep. Topography, organization, neurochemistry, digital tensor imaging and comparison with the chimpanzee and human.Brain structure & function · 2022Article
- Comparison of In Vivo and Ex Vivo Magnetic Resonance Imaging in a Rat Model for Glioblastoma-Associated Epilepsy.Diagnostics (Basel, Switzerland) · 2021Article
- Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury.Frontiers in neuroscience · 2021Article
- 7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project).European radiology experimental · 2020Article
- Diffusion tensor imaging and electrophysiology as robust assays to evaluate the severity of acute spinal cord injury in rats.BMC neurology · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to compare diffusion tensor imaging (DTI) parameters in vivo and ex vivo in the brain and to explore the effects of radiofrequency coil and number of excitations on ex vivo DTI parameters.
methodsSix Sprague-Dawley rat brains were used to obtain in vivo and ex vivo DTI maps with different coils and number of excitations. DTI parameters of white matter and grey matter including diffusivities, fractional anisotropy, and other dimensionless ratios (λ2/λ1, λ3/λ1, and λ2/λ3) were obtained from reconstruction maps. Comparisons of ex vivo signal-to-noise ratio with different coils and number of excitations were conducted.
resultsDiffusivities decreased significantly after fixation in all the selected white matter and grey matter regions of interest (all at p < 0.001). The diffusivities in white matter integrity decreased more than in grey matter integrity after fixation (all at p < 0.001). The ratio of λ2/λ3 in the major brain structures changed after fixation (most at p < 0.05). There were differences in major ex vivo brain structures in DTI parameters and signal-to-noise ratio between surface coil and volume coil, and between one and four excitations (most at p < 0.05).
conclusionThe impact of fixation, coil, and number of excitations on DTI parameters should be taken into consideration in clinical and experimental studies at 7.0 T.
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