Evidence map›Paper›PMID 30279998›Full record

ArticleTranslational vision science & technology2018

Comparison of Green Versus Blue Fundus Autofluorescence in

Philipp L Müller, Maximilian Pfau, Matthias M Mauschitz, Philipp T Möller, Johannes Birtel, Petrus Chang, Martin Gliem, Steffen Schmitz-Valckenberg, Monika Fleckenstein, Frank G Holz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  8. Observational
  9. Comparison between two multimodal imaging platforms: Nidek Mirante and Heidelberg Spectralis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  10. Stargardt disease: Multimodal imaging: A review.Clinical & experimental ophthalmology · 2021
    Review
  11. Review
  12. Multimodal Imaging Features of Optic Disc Drusen.American journal of ophthalmology · 2021
    Article
  13. Fundus autofluorescence imaging.Progress in retinal and eye research · 2021
    Review
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Philipp L MüllerDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Maximilian PfauDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Matthias M MauschitzDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Philipp T MöllerDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Johannes BirtelDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Petrus ChangDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Martin GliemDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Steffen Schmitz-ValckenbergDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Monika FleckensteinDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Frank G HolzDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Philipp HerrmannDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the interreader and intermodality agreement for grading of retinal pigment epithelium (RPE) atrophy lesion size in

methodsIn this cross-sectional case series, 97 eyes of 49 patients with RPE atrophy secondary to

resultsGAF- and BAF-based measurements of DDAF and QDAF showed high intermodality and interreader agreement concerning square-root lesion size, as well as shape descriptive parameters (perimeter and circularity). Interreader agreement of square-root lesion size was slightly, hence not significantly higher for GAF-based grading ([95% coefficients of repeatability, intraclass correlation coefficient] DDAF: 0.215 mm, 0.997; QDAF: 0.712 mm, 0.981) compared to BAF-based grading (DDAF: 0.232 mm, 0.997; QDAF: 0.764 mm, 0.978). However, DDAF-measurements revealed distinctly more reproducible results than QDAF-measurements. Foveal sparing did not interfere with intermodality agreement.

conclusionsBoth GAF- and BAF-based quantification of RPE atrophy showed very reliable results with possible superiority of GAF in the context of less energetic excitation light. TRANSLATIONAL RELEVANCE: The high interreader agreement qualifies the use of DDAF progression in GAF and BAF imaging as potential morphologic outcome measure for interventional clinical trials and disease monitoring.

Indexed as

atrophyinterreader correlationretinaretinal pigment epitheliumStargardt disease

Identifiers

PMID30279998
PMCPMC6166893
OpenAlexW2893443256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.