Evidence map›Paper›PMID 30279740›Full record

ArticleTheranostics2018

Neurogliovascular dysfunction in a model of repeated traumatic brain injury.

Conner Adams, Paolo Bazzigaluppi, Tina L Beckett, Jossana Bishay, Iliya Weisspapir, Adrienne Dorr, James R Mester, Joe Steinman, Lydiane Hirschler, Jan M Warnking and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Persistent dysmorphology and dysfunction of the brain microvasculature following repeated trauma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  12. Frequency selective neuronal modulation triggers spreading depolarizations in the rat endothelin-1 model of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  13. Optogenetic Interrogation of Circuits Following Neurotrauma.Frontiers in molecular neuroscience · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Conner AdamsUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Paolo BazzigaluppiUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Tina L BeckettSunnybrook Research Institute, Toronto, Ontario, Canada.
Jossana BishayUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Iliya WeisspapirSunnybrook Research Institute, Toronto, Ontario, Canada.
Adrienne DorrSunnybrook Research Institute, Toronto, Ontario, Canada.
James R MesterUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Joe SteinmanUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Lydiane HirschlerUniversité Grenoble Alpes, Grenoble Institut des Neurosciences, Grenoble, France.
Jan M WarnkingUniversité Grenoble Alpes, Grenoble Institut des Neurosciences, Grenoble, France.
Emmanuel L BarbierUniversité Grenoble Alpes, Grenoble Institut des Neurosciences, Grenoble, France.
JoAnne McLaurinSunnybrook Research Institute, Toronto, Ontario, Canada.
John G SledUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Bojana StefanovicUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.
Sunnybrook Research InstituteSunnybrook Hospital · CAGrenoble Institute of Neurosciences · FRHospital for Sick Children · CAInserm · FRUniversity of Toronto · CA

Funding

CIHR FRN 148521
6 · The paper itself

Abstract

Traumatic brain injury (TBI) research has focused on moderate to severe injuries as their outcomes are significantly worse than those of a mild TBI (mTBI). However, recent epidemiological evidence has indicated that a series of even mild TBIs greatly increases the risk of neurodegenerative and psychiatric disorders. Neuropathological studies of repeated TBI have identified changes in neuronal ionic concentrations, axonal injury, and cytoskeletal damage as important determinants of later life neurological and mood compromise; yet, there is a paucity of data on the contribution of neurogliovascular dysfunction to the progression of repeated TBI and alterations of brain function in the intervening period.

Indexed as

Disease Models, AnimalAnimalsBrain Injuries, TraumaticCerebrovascular DisordersMagnetic Resonance ImagingMiceMicroscopy, FluorescenceNeurogliaNeuronsOptogeneticsRecurrenceclosed head injuryneurovascularoptogeneticsrepeated TBI

Identifiers

PMID30279740
PMCPMC6160760
OpenAlexW2889661896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.