Evidence map›Paper›PMID 30279736›Full record

ArticleTheranostics2018

Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized

Christian Hundshammer, Miriam Braeuer, Christoph A Müller, Adam E Hansen, Mathias Schillmaier, Stephan Düwel, Benedikt Feuerecker, Steffen J Glaser, Axel Haase, Wilko Weichert and 7 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Review
  5. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
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  7. Article
  8. Article
  9. Review
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  11. Review
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Christian HundshammerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Miriam BraeuerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Christoph A MüllerDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Adam E HansenDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
Mathias SchillmaierDepartment of Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Stephan DüwelDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Benedikt FeuereckerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Steffen J GlaserDepartment of Chemistry, Technical University of Munich, 85748 Garching, Germany.
Axel HaaseMunich School of Bioengineering, Technical University of Munich, 85748 Garching, Germany.
Wilko WeichertGerman Consortium for Cancer Research (DKTK), 69120 Heidelberg, Germany.
Katja SteigerDepartment of Pathology, Klinikum rechts der Isar, Technical University Munich, 81675 München, Germany.
Jorge CabelloDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Franz SchillingDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Jan-Bernd HövenerSection for Biomedical Imaging, Molecular Imaging North Competence Center (MOINCC), Department for Radiology and Neuroradiology, University Medical Center Kiel, University Kiel.
Andreas KjærDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
Stephan G NekollaDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Markus SchwaigerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, 81675 München, Germany.
Klinikum rechts der Isar · DETechnical University of Munich · DEUniversity of Copenhagen · DKHeidelberg University · DEKiel University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern oncology aims at patient-specific therapy approaches, which triggered the development of biomedical imaging techniques to synergistically address tumor biology at the cellular and molecular level. PET/MR is a new hybrid modality that allows acquisition of high-resolution anatomic images and quantification of functional and metabolic information at the same time. Key steps of the Warburg effect-one of the hallmarks of tumors-can be measured non-invasively with this emerging technique. The aim of this study was to quantify and compare simultaneously imaged augmented glucose uptake and LDH activity in a subcutaneous breast cancer model in rats (MAT-B-III) and to study the effect of varying tumor cellularity on image-derived metabolic information.

Indexed as

AnaerobiosisMetabolic Networks and PathwaysAerobiosisAnimalsBreast NeoplasmsCarbon IsotopesDisease Models, AnimalFluorodeoxyglucose F18GlucoseHeterograftsImage Processing, Computer-AssistedL-Lactate DehydrogenaseMagnetic Resonance ImagingNeoplasm TransplantationPositron-Emission TomographyRatsCarbon-13Carbon IsotopesFluorodeoxyglucose F18GlucoseL-Lactate Dehydrogenase[18F]FDG-PETdiffusion-weighted imagingDNPhyperpolarized 13C-MRSImultimodal imagingNMRPET/MRspectroscopy

Identifiers

PMID30279736
PMCPMC6160766
OpenAlexW2891804009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.