Evidence map›Paper›PMID 30279735›Full record

ArticleTheranostics2018

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.

Chantal J M van Opbergen, Charlotte D Koopman, Bart J M Kok, Thomas Knöpfel, Sabine L Renninger, Michael B Orger, Marc A Vos, Toon A B van Veen, Jeroen Bakkers, Teun P de Boer

Open access · goldAbstract readValidation Study
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Zebrafish in Cardiovascular Disease Research: from Model to Application.International journal of biological sciences · 2026
    Review
  2. Article
  3. Article
  4. Genes · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
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  10. Article
  11. Article
  12. Article
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  15. Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021
    Review
  16. A Heterozygous Mutation in Cardiac Troponin T Promotes CaJournal of cardiovascular development and disease · 2021
    Article
  17. The zebrafishProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Mechanisms ofJournal of cardiovascular development and disease · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Chantal J M van OpbergenDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Charlotte D KoopmanDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Bart J M KokDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Thomas KnöpfelLaboratory for Neuronal Circuit Dynamics, Imperial College London, London, UK.
Sabine L RenningerChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Michael B OrgerChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Marc A VosDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Toon A B van VeenDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Jeroen BakkersDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
Teun P de BoerDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM, Utrecht, The Netherlands.
University Medical Center Utrecht · NLChampalimaud Foundation · PTNIHR Imperial Biomedical Research Centre · GBRoyal Netherlands Academy of Arts and Sciences · NL

Funding

Near Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology (AOE)U01NS099573 · NINDS · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI ANTIC, SRDJAN D, KNOPFEL, THOMAS · 2016 to 2018
$2.9M
CIHRNINDS NIH HHS U01 NS099573
6 · The paper itself

Abstract

Cardiac arrhythmias are among the most challenging human disorders to diagnose and treat due to their complex underlying pathophysiology. Suitable experimental animal models are needed to study the mechanisms causative for cardiac arrhythmogenesis. To enable

Indexed as

Electrophysiological PhenomenaAnimalsAnti-Arrhythmia AgentsBiological ClocksElectrophysiologic Techniques, CardiacHeartHeart RateHumansIsoproterenolMicroscopy, FluorescenceOptogeneticsPiperidinesPropranololPyridinesZebrafishAnti-Arrhythmia AgentsE 4031IsoproterenolPiperidinesPropranololPyridineschimeric VSFP-butterfly CYGCaMP6fin vivo cardiac cellular electrophysiologyOptogeneticszebrafish

Identifiers

PMID30279735
PMCPMC6160779
OpenAlexW2892170133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.