Evidence map›Paper›PMID 30279620›Full record

ArticleJournal of clinical biochemistry and nutrition2018

Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine.

Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Yuichi Ikegami, Norihiro Kotani, Akira Shimada, Mitsuhiko Noda, Takayuki Murakoshi

Open access · diamondAbstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Takanari NakanoDepartment of Biochemistry, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Ikuo InoueDepartment of Diabetes and Endocrinology, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Yasuhiro TakenakaDepartment of Physiology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8602, Japan.
Yuichi IkegamiDepartment of Physiology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8602, Japan.
Norihiro KotaniDepartment of Biochemistry, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Akira ShimadaDepartment of Diabetes and Endocrinology, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Mitsuhiko NodaDepartment of Diabetes and Endocrinology, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Takayuki MurakoshiDepartment of Biochemistry, Faculty of Medicine, Saitama Medical University, Iruma, Saitama 350-0495, Japan.
Saitama Medical University · JPNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of the absorption inhibition. Intestine-mediated reverse cholesterol transport, or trans-intestinal cholesterol efflux (TICE), provides the major part of the increase of FNS excretion. However, it is unknown whether plant sterols stimulate TICE or not. We have shown previously that TICE can be evaluated by brush border membrane (BBM)-to-lumen cholesterol efflux. Thus, we examined whether luminal plant sterols stimulate BBM-to-lumen cholesterol efflux in the intestinal tract or not in mice. Cannulated upper jejunum that had been pre-labeled with orally given

Indexed as

cholesterol absorptionphytosterolssmall intestinetrans-intestinal cholesterol efflux

Identifiers

PMID30279620
PMCPMC6160726
OpenAlexW2794535121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.