ArticleScientific reports2018
Reconstructing the evolutionary history of pandemic foot-and-mouth disease viruses: the impact of recombination within the emerging O/ME-SA/Ind-2001 lineage.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 83 citations in OpenAlex.
- Buffaloed in Brandenburg: Germany's first brush with foot-and-mouth disease after four decades of freedom.Science advances · 2026Article
- Differential effects of foot-and-mouth disease infection and vaccination on fertility of Holstein-Friesian heifers: Evidence from a within-animal retrospective study in Indonesia.Veterinary world · 2026Article
- Molecular Epidemiology and Co-Circulation of Foot-and-Mouth Disease Serotypes in Ghana, 2024.Viruses · 2026Article
- Article
- Phylogeographic and Host Interface Analyses Reveal the Evolutionary Dynamics of SAT3 Foot-And-Mouth Disease Virus.Viruses · 2025Article
- Molecular characterisation of foot-and-mouth disease viruses collected from Bangladesh during 2021-23: evidence for trans-pool spread of exotic viral lineages.Veterinary research · 2025Article
- VP1 region-based molecular characterization of foot-and-mouth disease virus serotype O from clinical cases in Haryana, India.BMC veterinary research · 2025Article
- Wild Fauna in Oman: Foot-and-Mouth Disease Outbreak in Arabyan Oryx (Animals : an open access journal from MDPI · 2025Article
- Epidemiology and economics of foot-and-mouth disease: current understanding and knowledge gaps.Veterinary research · 2025Review
- Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle.Journal of virology · 2025Article
- A novel immunoinformatic approach for design and evaluation of heptavalent multiepitope foot-and-mouth disease virus vaccine.BMC veterinary research · 2025Article
- Phylogenetic Characterization and Pathogenicity in Cattle and Pigs of Foot-and-Mouth Disease Viruses Circulating in Myanmar Between 2016 and 2022.Transboundary and emerging diseases · 2025Article
- Comparative analysis of VP1 epitopic variation among different isolates of foot-and-mouth disease virus type-O during an outbreak in the Punjab province of Pakistan.Veterinary research forum : an international quarterly journal · 2025Article
- Molecular characterization ofVeterinary world · 2024Article
- Multiple incursions of foot-and-mouth disease virus serotype O into the Republic of Korea between 2010 and 2019.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Article
- Identification of Conserved Linear Epitopes on Viral Protein 2 of Foot-and-Mouth Disease Virus Serotype O by Monoclonal Antibodies 6F4.D11.B6 and 8D6.B9.C3.Antibodies (Basel, Switzerland) · 2024Article
- Comparing Phylogeographies to Reveal Incompatible Geographical Histories within Genomes.Molecular biology and evolution · 2024Article
- Foot and Mouth Disease Vaccine Matching and Post-Vaccination Assessment in Abu Dhabi, United Arab Emirates.Veterinary sciences · 2024Article
- Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018.Heliyon · 2024Article
- Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Emirate of Abu Dhabi, United Arab Emirates.Veterinary sciences · 2024Article
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Authors and funding
30 authors at 13 institutions in 13 countries.
Funding
Abstract
Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and predict the risks of incursion into FMD-free countries. Global expansion of a single FMDV lineage is rare but can result in severe economic consequences. Using extensive sequence data we have reconstructed the global space-time transmission history of the O/ME-SA/Ind-2001 lineage (which normally circulates in the Indian sub-continent) providing evidence of at least 15 independent escapes during 2013-2017 that have led to outbreaks in North Africa, the Middle East, Southeast Asia, the Far East and the FMD-free islands of Mauritius. We demonstrated that sequence heterogeneity of this emerging FMDV lineage is accommodated within two co-evolving divergent sublineages and that recombination by exchange of capsid-coding sequences can impact upon the reconstructed evolutionary histories. Thus, we recommend that only sequences encoding the outer capsid proteins should be used for broad-scale phylogeographical reconstruction. These data emphasise the importance of the Indian subcontinent as a source of FMDV that can spread across large distances and illustrates the impact of FMDV genome recombination on FMDV molecular epidemiology.
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