ArticleScientific reports2018
In Utero Heat Stress Alters the Offspring Epigenome.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 103 citations in OpenAlex.
- Nutritional Strategies to Mitigate Heat Stress in Cattle: A Narrative Review.Microorganisms · 2026Review
- Metabolic and productive responses to heat stress in transition dairy cows: Interactions with calving stage, season, and farm management.International journal of biometeorology · 2026Article
- Maternal heat abatement during gestation alters growth, immunity, thermotolerance, and hepatic gene expression in beef offspring during backgrounding.Frontiers in veterinary science · 2026Article
- Review
- Transgenerational skin adaptations to late-gestation heat stress in great-granddaughters.JDS communications · 2025Article
- Biological Mechanisms for Allen's Rule: DNA Methylation as Mediator of the Association Between In Utero Exposure to Environmental Heat and Tibial Growth in Childhood.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Heat stress induces specific methylation, transcriptomic and metabolic pattern in dairy cows and their female progeny.Scientific reports · 2025Article
- Effects of the Prenatal Maternal Health Status on Calf Disease Prevalences and Respective Genetic Parameter Estimates in German Holstein Cattle.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Molecular responses of chicken embryos to maternal heat stress through DNA methylation and gene expression: a pilot study.Environmental epigenetics · 2025Article
- Quantification of the effect of in utero events on lifetime resilience in dairy cows.Journal of dairy science · 2024Article
- Genotype-by-gestational thermal environment interaction and its impact on the future performance of tropical composite beef cattle offspring.Journal of animal science · 2024Article
- Animal Wellness: The Power of Multiomics and Integrative Strategies: Multiomics in Improving Animal Health.Veterinary medicine international · 2024Review
- Article
- A Pilot Study on Across-Generation Impacts of Maternal Heat Stress on Blood Metabolites of Female Holstein Dairy Calves.Metabolites · 2023Article
- Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress.Frontiers in veterinary science · 2023Review
- The Impact of Heat Stress on Immune Status of Dairy Cattle and Strategies to Ameliorate the Negative Effects.Animals : an open access journal from MDPI · 2022Review
- In utero hyperthermia in late gestation derails dairy calf early-life mammary development.Journal of animal science · 2022Article
- Carry-over effects of dry period heat stress on the mammary gland proteome and phosphoproteome in the subsequent lactation of dairy cows.Scientific reports · 2022Article
- Effects of Seasonal Heat Stress during Late Gestation on Growth Performance, Metabolic and Immuno-Endocrine Parameters of Calves.Animals : an open access journal from MDPI · 2022Article
- Consequences of maternal heat stress at different stages of embryonic and fetal development on dairy cows' progeny.Animal frontiers : the review magazine of animal agriculture · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to intrauterine heat stress during late gestation affects offspring performance into adulthood. However, underlying mechanistic links between thermal insult in fetal life and postnatal outcomes are not completely understood. We examined morphology, DNA methylation, and gene expression of liver and mammary gland for bull calves and heifers that were gestated under maternal conditions of heat stress or cooling (i.e. in utero heat stressed vs. in utero cooled calves). Mammary tissue was harvested from dairy heifers during their first lactation and liver from bull calves at birth. The liver of in utero heat stressed bull calves contained more cells and the mammary glands of in utero heat stressed heifers were comprised of smaller alveoli. We identified more than 1,500 CpG sites differently methylated between maternal treatment groups. These CpGs were associated with approximately 400 genes, which play a role in processes, such as development, innate immune defense, cell signaling, and transcription and translation. We also identified over 100 differentially expressed genes in the mammary gland with similar functions. Interestingly, fifty differentially methylated genes were shared by both bull calf liver and heifer mammary gland. Intrauterine heat stress alters the methylation profile of liver and mammary DNA and programs their morphology in postnatal life, which may contribute to the poorer performance of in utero heat stressed calves.
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