ArticleScientific reports2018
Spider silk proteome provides insight into the structural characterization of Nephila clavipes flagelliform spidroin.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analysis reveals materiomic relationships in major ampullate silk across the spider phylogeny.Journal of the Royal Society, Interface · 2020Pooled it
- Post-translational modifications of silk proteins.RSC chemical biology · 2026Review
- Backyard Proteomics: A Case Study with the Black Widow Spider.Journal of proteome research · 2025Article
- Recombinant production of spider silk protein in Physcomitrella photobioreactors.Plant cell reports · 2025Article
- Article
- Recombinant fibrous protein biomaterials meet skin tissue engineering.Frontiers in bioengineering and biotechnology · 2024Review
- Factors Influencing Properties of Spider Silk Coatings and Their Interactions within a Biological Environment.Journal of functional biomaterials · 2023Review
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- Complete Sequences of the Velvet Worm Slime Proteins Reveal that Slime Formation is Enabled by Disulfide Bonds and Intrinsically Disordered Regions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Complexity of Spider Dragline Silk.Biomacromolecules · 2022Review
- Recombinant Spider Silk: Promises and Bottlenecks.Frontiers in bioengineering and biotechnology · 2022Review
- Recombinant Proteins-Based Strategies in Bone Tissue Engineering.Biomolecules · 2021Review
- Critical role of minor eggcase silk component in promoting spidroin chain alignment and strong fiber formation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Correlation between protein secondary structure and mechanical performance for the ultra-tough dragline silk of Darwin's bark spider.Journal of the Royal Society, Interface · 2021Article
- Molecular Dynamics of Synthetic Flagelliform Silk Fiber Assembly.Macromolecular materials and engineering · 2021Article
- Thermal, structural and mechanical characterization ofHeliyon · 2020Article
- Spider Silk for Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capture spiral of web from N. clavipes spider consists of a single type of spidroin - the flagelliform silk protein, a natural material representing a combination of strength and high elasticity. Flagelliform spider silk is the most extensible silk fibre produced by orb weaver spiders and the structure of this remarkable material is still largely unknown. In the present study we used a proteomic approach to elucidate the complete sequence and the post-translational modifications of flagelliform silk proteins. The long sequence of flagelliform silk protein presents 45 hydroxylated proline residues, which may contribute to explain the mechanoelastic property of these fibres, since they are located in the GPGGX motif. The 3D-structure of the protein was modelled considering the three domains together, i.e., the N- and C-terminal non-repetitive domains, and the central repetitive domain. In the resulting molecular model there is a predominance of random structures in the solid fibres of the silk protein. The N-terminal domain is composed of three α-helices and the C-terminal domain is composed of one small helical section. Proteomic data reported herein may be relevant for the development of novel approaches for the synthetic or recombinant production of novel silk-based spider polymers.
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