Evidence map›Paper›PMID 30279520›Full record

ArticleScientific reports2018

An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation.

Malorie Blancard, Amal Debbiche, Koichi Kato, Christelle Cardin, Guichard Sabrina, Estelle Gandjbakhch, Vincent Probst, Michel Haissaguerre, Fabrice Extramiana, Mélèze Hocini and 4 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. AHeartRhythm case reports · 2025
    Article
  3. Review
  4. Review
  5. CACNA1C-Related Channelopathies.Handbook of experimental pharmacology · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Malorie BlancardINSERM, UMR_S1166, Paris, France.ORCID http://orcid.org/0000-0003-1174-1069
Amal DebbicheINSERM, UMR_S1166, Paris, France.
Koichi KatoINSERM, UMR_S1166, Paris, France.
Christelle CardinUniversity Hospital Rangueil, Toulouse, France.
Guichard SabrinaUniversity of Bern, Institute of Biochemistry and Molecular Medicine, Bern, Switzerland.
Estelle GandjbakhchINSERM, UMR_S1166, Paris, France.
Vincent ProbstCHU Nantes, L'institut du thorax, Service de Cardiologie, Nantes, France.
Michel HaissaguerreL'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France.
Fabrice ExtramianaAP-HP, Hôpital Bichat, Département de Cardiologie, Centre de Référence des Maladies Cardiaques Héréditaires, Paris, France.
Mélèze HociniL'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France.
Geoffroy OlivierCHU Sud Réunion, La Réunion, France.
Antoine LeenhardtAP-HP, Hôpital Bichat, Département de Cardiologie, Centre de Référence des Maladies Cardiaques Héréditaires, Paris, France.ORCID http://orcid.org/0000-0001-7368-4528
Pascale GuicheneyINSERM, UMR_S1166, Paris, France.ORCID http://orcid.org/0000-0002-7663-2050
Jean-Sébastien RougierUniversity of Bern, Institute of Biochemistry and Molecular Medicine, Bern, Switzerland. jean-sebastien.rougier@ibmm.unibe.ch.ORCID http://orcid.org/0000-0002-8710-0260
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRUniversité de Bordeaux · FRUniversity of Bern · CHCentre Hospitalier Universitaire de La Réunion · FRHôpital Rangueil · FRInstitut du Thorax · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Ca

Indexed as

AdultArrhythmias, CardiacBariumBlack PeopleBrugada SyndromeCalciumCalcium ChannelsCalcium Channels, L-TypeCations, DivalentCohort StudiesFemaleGene ExpressionGenetic Predisposition to DiseaseHeart ArrestHumansIon TransportBariumCACNA1C protein, humanCACNA2D1 protein, humanCACNB2 protein, humanCalciumCalcium ChannelsCalcium Channels, L-TypeCations, Divalent

Identifiers

PMID30279520
PMCPMC6168548
OpenAlexW2894283312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.