ArticleMucosal immunology2019
NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia.
Article in Mucosal immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Aurora A exacerbates antibiotic-resistant Staphylococcus aureus infection through ASC phosphorylation.EMBO reports · 2026Article
- The challenge of cell death switching in inflammasome-targeted therapies for bacterial and viral infections.Communications biology · 2026Review
- Streptococcus anginosus activates the NLRP3 inflammasome to promote inflammatory responses from macrophages.Journal of leukocyte biology · 2026Article
- NLRC4 deficiency improves host protection during sepsis by regulating macrophage and T-cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Targeting inflammasome, IL-1β, and coagulation in melioidosis.Frontiers in microbiology · 2026Review
- Advances inMicroorganisms · 2025Review
- CXCL1 augments host defense against Legionella pneumophila through the IL-18-IFN-γ axis and neutrophil homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation.Scientific reports · 2025Article
- NLRP3 promotes inflammatory signaling and IL-1β cleavage in acute lung injury caused by cell wall extract of Lactobacillus casei.Communications biology · 2025Article
- Targeting necroptosis: a promising avenue for respiratory disease treatment.Cell communication and signaling : CCS · 2024Review
- From Host Defense to Metabolic Signatures: Unveiling the Role of γδ T Cells in Bacterial Infections.Biomolecules · 2024Review
- NLRP6 negatively regulates host defense against polymicrobial sepsis.Frontiers in immunology · 2024Article
- Necroptosis in bacterial infections.Frontiers in immunology · 2024Review
- Innate immune responses in pneumonia.Pneumonia (Nathan Qld.) · 2023Review
- Revealing novel pyroptosis-related therapeutic targets for sepsis based on machine learning.BMC medical genomics · 2023Article
- Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation.Frontiers in immunology · 2023Review
- [NLRC4 plays a regulatory role in F. nucleatum-induced pyroptosis in macrophages].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Identification of key genes related to immune cells in patients with gram-negative sepsis based on weighted gene co-expression network analysis.Annals of translational medicine · 2022Article
- Regulation of emergency granulopoiesis during infection.Frontiers in immunology · 2022Review
- Bacterial subversion of NLR-mediated immune responses.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gram-positive pathogens, including Staphylococcus aureus, cause necrotizing pneumonia. The central feature of S. aureus pneumonia is toxin-induced necroptosis of immune and resident cells, which impedes host defense. However, the role of the NLRC4 in the lung following S. aureus infection remains elusive. Here, we demonstrate that S. aureus activates the NLRC4 to drive necroptosis and IL-18 production, which impaired IL-17A-dependent neutrophil-mediated host susceptibility. In particular, Nlrc4
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Registered trials
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