ArticleScientific reports2018
The mapping of cancer incidence and mortality trends in the UK from 1980-2013 reveals a potential for overdiagnosis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Thyroid Incidentalomas in Association With Low-Dose Computed Tomography in the National Lung Screening Trial.American journal of epidemiology · 2020Trial
- Cancer trends in England in younger adults from 2001-2023: comparing incidence, mortality and stage at diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Thyroid cancer incidence in cohorts exposed in childhood toRadiation and environmental biophysics · 2024Article
- Variation in harms and benefits of prostate-specific antigen screening for prostate cancer by socio-clinical risk factors: A rapid review.BJUI compass · 2024Review
- 25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis.BMJ (Clinical research ed.) · 2024Article
- Inter-observer agreement among specialists in the diagnosis of oral potentially malignant disorders and oral cancer using store-and-forward technology.Clinical oral investigations · 2023Article
- Deceptive measures of progress in the NHS long-term plan for cancer: case-based vs. population-based measures.British journal of cancer · 2023Review
- Disparities in care and outcomes for primary liver cancer in England during 2008-2018: a cohort study of 8.52 million primary care population using the QResearch database.EClinicalMedicine · 2023Article
- Increased Early Cancer Diagnosis: Unveiling Immune-Cancer Biology to Explain Clinical "Overdiagnosis".Cancers · 2023Article
- An Epidemiologic Analysis of Melanoma Overdiagnosis in the United States, 1975-2017.The Journal of investigative dermatology · 2022Article
- Incidence trends for twelve cancers in younger adults-a rapid review.British journal of cancer · 2022Review
- The justification of non-obstetric ultrasound referrals: A safe and effective practice.Ultrasound (Leeds, England) · 2022Article
- Dermatomyositis and malignancy: should all patients with dermatomyositis undergo malignancy screening?Annals of translational medicine · 2021Review
- Estimating the magnitude of cancer overdiagnosis in Australia.The Medical journal of Australia · 2020Article
- Article
- Trends in cervical cancer and its precursor forms to evaluate screening policies in a mid-sized Northeastern Brazilian city.PloS one · 2020Article
- Assessing trends of breast cancer and carcinoma in situ to monitor screening policies in developing settings.Scientific reports · 2019Article
- The Cancer Drugs Fund in Practice and Under the New Framework.PharmacoEconomics · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of cancer in the United Kingdom has increased significantly over the last four decades. The aim of this study was to examine trends in UK cancer incidence and mortality by cancer site and assess the potential for overdiagnosis. Using Cancer Research UK incidence and mortality data for the period (1971-2014) we estimated percentage change in incidence and mortality rates and the incidence-mortality ratio (IMR) for cancers in which incidence had increased >50%. Incidence and mortality trend plots were used to assess the potential for overdiagnosis. Incidence rates increased from 67% (uterine) to 375% (melanoma). Change in mortality rates ranged from -69% (cervical) to +239% (liver). The greatest divergences occurred in uterine (IMR = 132), prostate (IMR = 9.6), oral (IMR = 9.8) and thyroid cancer (IMR = 5.3). Only in liver cancer did mortality track incidence (IMR = 1.1). For four cancer sites; uterine, prostate, oral and thyroid, incidence and mortality trends are suggestive of overdiagnosis. Trends in melanoma and kidney cancer suggest potential overdiagnosis and an underlying increase in true risk, whereas for cervical and breast cancer, trends may also reflect improvements in treatments or earlier diagnosis. A more detailed analysis is required to fully understand these patterns.
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