ArticleNature communications2018
Megahertz serial crystallography.
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58 citing papers in PubMed.
- Lysozyme revisited: evaluating models of a reference protein in structural biology.Current research in structural biology · 2026Article
- PEO-sheathed liquid jets increase sample delivery stability for serial femtosecond X-ray crystallography.Scientific reports · 2026Article
- Viscoelastic characterization of the lipid cubic phase provides insights into high-viscosity extrusion injection for XFEL experiments.Scientific reports · 2025Article
- Standard Sample Preparation for Serial Femtosecond Crystallography.Biomolecules · 2025Review
- Probing the modulation of enzyme kinetics by multi-temperature, time-resolved serial crystallography.Nature communications · 2025Article
- Comprehensive characterization of gas dynamic virtual nozzles for x-ray free-electron laser experiments.Structural dynamics (Melville, N.Y.) · 2024Article
- Microsecond time-resolved X-ray scattering by utilizing MHz repetition rate at second-generation XFELs.Nature methods · 2024Article
- Time-resolved crystallography of boric acid binding to the active site serine of the β-lactamase CTX-M-14 and subsequent 1,2-diol esterification.Communications chemistry · 2024Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- A comparative review of time-resolved x-ray and electron scattering to probe structural dynamics.Structural dynamics (Melville, N.Y.) · 2024Review
- Direct laser writing-enabled 3D printing strategies for microfluidic applications.Lab on a chip · 2024Review
- Kilohertz droplet-on-demand serial femtosecond crystallography at the European XFEL station FXE.Structural dynamics (Melville, N.Y.) · 2024Article
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- A 3D-MICROPRINTED COAXIAL NOZZLE FOR FABRICATING LONG, FLEXIBLE MICROFLUIDIC TUBING.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2024Article
- Characterization of Biological Samples Using Ultra-Short and Ultra-Bright XFEL Pulses.Advances in experimental medicine and biology · 2024Article
- Structure of theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook.Structure (London, England : 1993) · 2023Review
- Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS).Communications biology · 2023Article
- A 64k pixel CMOS-DEPFET module for the soft X-rays DSSC imager operating at MHz-frame rates.Scientific reports · 2023Article
- Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography.Nature communications · 2023Article
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Authors and funding
126 authors.
Max O WiedornCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-0856-2695
Dominik OberthürCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Richard BeanEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Robin SchubertThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Nadine WernerInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.
Brian AbbeyAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.ORCID http://orcid.org/0000-0001-6504-0503
Martin AepfelbacherInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.
Luigi AdrianoDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Aschkan AllahgholiDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Nasser Al-QudamiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Jakob AndreassonLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.
Steve AplinCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Salah AwelCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Kartik AyyerCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-6881-564X
Saša BajtDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Imrich BarákInstitute of Molecular Biology, SAS, Dubravska cesta 21, 845 51, Bratislava, Slovakia.ORCID http://orcid.org/0000-0002-3690-404X
Sadia BariDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-3985-2051
Johan BieleckiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Sabine BothaThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Djelloul BoukhelefEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Wolfgang BrehmCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Sandor BrockhauserEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-9700-4803
Igor CheviakovInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.
Matthew A ColemanLawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA.
Francisco Cruz-MazoDepart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de Sevilla, 41092, Sevilla, Spain.ORCID http://orcid.org/0000-0002-3765-5540
Cyril DanilevskiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Connie DarmaninAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
R Bruce DoakMax Planck Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany.
Martin DomarackyCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4624-023X
Katerina DörnerEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Yang DuCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Hans FangohrEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Holger FleckensteinCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Matthias FrankLawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA.ORCID http://orcid.org/0000-0002-5244-0791
Petra FrommeSchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ, 85287-1604, USA.
Alfonso M Gañán-CalvoDepart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de Sevilla, 41092, Sevilla, Spain.ORCID http://orcid.org/0000-0002-7552-6184
Yaroslav GevorkovCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9273-7648
Klaus GiewekemeyerEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Helen Mary GinnDivision of Structural Biology, Headington, Oxford, OX3 7BN, UK.
Heinz GraafsmaDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Rita GraceffaEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Dominic GreiffenbergPaul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland.
Lars GumprechtCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Peter GöttlicherDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Janos HajduLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.
Steffen HaufEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Michael HeymannDepartment of Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, 82152, Martinsried, Germany.ORCID http://orcid.org/0000-0002-9278-8207
Susannah HolmesAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
Daniel A HorkeCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-9862-8108
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, USA.
Siegfried ImlauCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Alexander KaukherEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Yoonhee KimEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Alexander KlyuevDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Juraj KnoškaCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7258-6256
Bostjan KobeSchool of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0001-9413-9166
Manuela KuhnDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Christopher KupitzPhysics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
Jochen KüpperCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4395-9345
Janine Mia Lahey-RudolphCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Torsten LaurusDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Karoline Le CongInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.
Romain LetrunEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-0569-5193
P Lourdu XavierCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Luis MaiaEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Filipe R N C MaiaLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.ORCID http://orcid.org/0000-0002-2141-438X
Valerio MarianiCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Marc MesserschmidtEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Markus MetzCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Davide MezzaPaul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland.ORCID http://orcid.org/0000-0003-2439-6348
Thomas MichelatEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-5689-8759
Grant MillsEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Diana C F MonteiroThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.ORCID http://orcid.org/0000-0002-6318-7306
Andrew MorganCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-9163-4249
Kerstin MühligLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.
Anna MunkeLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.ORCID http://orcid.org/0000-0002-5510-2245
Astrid MünnichEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Julia NetteThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Keith A NugentAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe University, Bundoora, VIC, 3086, Australia.
Theresa NuguidInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607, Hamburg, Germany.
Allen M OrvilleDiamond Light Source, Research Complex at Harwell, and University of Oxford, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK.
Suraj PandeyPhysics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
Gisel PenaCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Pablo Villanueva-PerezCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Jennifer PoehlsenDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Gianpietro PrevitaliEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Lars RedeckeInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.
Winnie Maria RiekehrInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Holger RohdeInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.
Adam RoundEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Tatiana SafenreiterCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Iosifina SarrouCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Tokushi SatoCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Marius SchmidtPhysics Department, University of Wisconsin-Milwaukee, 3135 N. Maryland Ave, Milwaukee, WI, 53211, USA.
Bernd SchmittPaul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland.ORCID http://orcid.org/0000-0002-5778-0680
Robert SchönherrInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Joachim SchulzEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Jonas A SellbergBiomedical and X-Ray Physics, Department of Applied Physics, AlbaNova University Center, KTH Royal Institute of Technology, Stockholm, 106 91, Sweden.ORCID http://orcid.org/0000-0003-2793-5052
M Marvin SeibertLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Uppsala, 751 24, Sweden.
Carolin SeuringCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-1000-0859
Megan L ShelbyLawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA, 94550, USA.
Robert L ShoemanMax Planck Institute for Medical Research, Jahnstr. 29, 69120, Heidelberg, Germany.
Marcin SikorskiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Alessandro SilenziEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Claudiu A StanPhysics Department, Rutgers University Newark, Newark, NJ, 07102, USA.ORCID http://orcid.org/0000-0002-9809-4521
Xintian ShiPaul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland.
Stephan SternCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Jola Sztuk-DambietzEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Janusz SzubaEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Aleksandra TolstikovaCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Martin TrebbinThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Ulrich TrunkDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7951-4183
Patrik VagovicCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Thomas VeInstitute for Glycomics, Griffith University, Southport, QLD, 4222, Australia.ORCID http://orcid.org/0000-0002-0113-1905
Britta WeinhausenEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Thomas A WhiteCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Krzysztof WronaEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Chen XuEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Oleksandr YefanovCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Nadia ZatsepinDepartment of Physics, Arizona State University, Tempe, AZ, 85287, USA.
Jiaguo ZhangPaul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen, Switzerland.
Markus PerbandtThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Adrian P MancusoEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Christian BetzelThe Hamburg Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Henry ChapmanCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. henry.chapman@desy.de.ORCID http://orcid.org/0000-0002-4655-1743
Anton BartyCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. anton.barty@desy.de.
Funding
Technology development for biological imaging with x-ray free electron lasersR01GM117342 · NIGMS · LAWRENCE LIVERMORE NATIONAL SECURITY, LLC · PI FRANK, MATTHIAS · 2016 to 2024
$4.8MFemtosecond nano-crystallography of membrane proteinsR01GM095583 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI FROMME, PETRA · 2010 to 2023
$4.3MDeutsche Forschungsgemeinschaft (German Research Foundation) DFG-EXC1074European Research Council 609920Helmholtz-Gemeinschaft (Helmholtz Gemeinschaft) Project oriented fundsNIGMS NIH HHS R01 GM095583NIGMS NIH HHS R01 GM117342Wellcome Trust
Abstract
The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
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