Evidence map›Paper›PMID 30279458›Full record

ReviewMolecular psychiatry2019

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks.

Alistair Perry, Gloria Roberts, Philip B Mitchell, Michael Breakspear

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  10. Network-based analysis of differential white matter connectivity in major depressive disorder with and without comorbid anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alistair PerryQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. perry@mpib-berlin.mpg.de.ORCID http://orcid.org/0000-0002-0794-1538
Gloria RobertsSchool of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Randwick, NSW, Australia.
Michael BreakspearQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. michael.breakspear@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0003-4943-3969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The notion that specific cognitive and emotional processes arise from functionally distinct brain regions has lately shifted toward a connectivity-based approach that emphasizes the role of network-mediated integration across regions. The clinical neurosciences have likewise shifted from a predominantly lesion-based approach to a connectomic paradigm-framing disorders as diverse as stroke, schizophrenia (SCZ), and dementia as "dysconnection syndromes". Here we position bipolar disorder (BD) within this paradigm. We first summarise the disruptions in structural, functional and effective connectivity that have been documented in BD. Not surprisingly, these disturbances show a preferential impact on circuits that support emotional processes, cognitive control and executive functions. Those at high risk (HR) for BD also show patterns of connectivity that differ from both matched control populations and those with BD, and which may thus speak to neurobiological markers of both risk and resilience. We highlight research fields that aim to link brain network disturbances to the phenotype of BD, including the study of large-scale brain dynamics, the principles of network stability and control, and the study of interoception (the perception of physiological states). Together, these findings suggest that the affective dysregulation of BD arises from dynamic instabilities in interoceptive circuits which subsequently impact on fear circuitry and cognitive control systems. We describe the resulting disturbance as a "psychosis of interoception".

Indexed as

Bipolar DisorderBrainCerebral CortexCognitionConnectomeEmotionsFemaleHumansMaleNerve NetPrefrontal CortexPsychotic DisordersSchizophrenia

Identifiers

PMID30279458
PMCPMC6756092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.