ArticleScientific reports2018
Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington's Disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Decreased Physical Activity as an Early Digital Biomarker in Huntington's Disease: A One-Year Observational Study.Brain and behavior · 2026Observational
- Learning effects during balance analysis on a modified posturomed-platform in healthy dogs.BMC veterinary research · 2026Article
- Editorial: Digital biomarkers in movement disorders.Frontiers in neurology · 2025Article
- Exploring relationships among gait, balance, and physical activity in individuals with Huntington's disease.Journal of Huntington's disease · 2024Article
- Change of gait after unilateral vestibular neuritis: a prospective longitudinal observation study.Scientific reports · 2021Observational
- Torque variability of the plantar flexors in people with Huntington's disease.American journal of translational research · 2021Article
- Approach to Posture and Gait in Huntington's Disease.Frontiers in bioengineering and biotechnology · 2021Review
- Rate of torque development and striatal shape in individuals with prodromal Huntington's disease.Scientific reports · 2020Article
- Quantifying Postural Control in Premanifest and Manifest Huntington Disease Using Wearable Sensors.Neurorehabilitation and neural repair · 2020Observational
- Dual tasking impairments are associated with striatal pathology in Huntington's disease.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p < 0.05). Premanifest and manifest HD demonstrated significantly lower endpoint excursion (p < 0.001), maximum excursion (p ≤ 0.001), and directional control (p ≤ 0.004) values than healthy individuals on the LOS test. Deficits in LOS were found to manifest on the left side of premanifest HD. Significant but low associations were observed between UHDRS-TMS, disease burden score, diagnostic confidence level, SOT conditions and SOT composite score. We confirm here that individuals with premanifest and manifest HD display significant impairments in static and dynamic postural stability. Dynamic posturography assessments should be considered as clinical endpoints for future disease modifying trials.
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