ArticleScientific reports2018
Exposure to heat-stress environment affects the physiology, circulation levels of cytokines, and microbiome in dairy cows.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 147 citations in OpenAlex.
- Distinct physiological and immunoendocrine responses in indigenous dairy heifers during cold-humid (THI-50) vs. hot dry (THI-76) climatic conditions.Tropical animal health and production · 2026Article
- Unraveling the impact of heat stress on meat quality: integrating physiology, epigenetics, and postmortem biochemistry.NPJ science of food · 2026Review
- Whole blood response to lipopolysaccharide depends on both physiological and genetic factors in dairy cattle.Veterinary research · 2026Article
- Host-microbiome interplay supports heat stress resilience in zebu calves.Animal microbiome · 2026Article
- Targeting Inflammation with Dietary ω-3 Polyunsaturated Fatty Acids Improved Lipid Mobilization and Flux in Heat-Stressed Wether Lambs.Metabolites · 2026Article
- Research progress on the mechanisms and intervention strategies of microbiota-gut-brain axis dysfunction under heat stress.Frontiers in physiology · 2026Review
- Data-driven enterosignatures link gut microbiome reorganization to heat stress responses in lactating sows.Frontiers in microbiology · 2026Article
- The intricate relationship between stress and animal welfare: from historical perspective to new avenues.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Unveiling the rumen-microbiome-brain circuit: a unique dimension of gut-brain axis in ruminants.Journal of animal science and biotechnology · 2025Review
- Antioxidant status, cytokine level, immunocompetence, Hsp70 mRNA expression, and selenium metabolism of goats fed higher selenium under heat stress conditions.Scientific reports · 2025Article
- Effect of heat stress on some serum and reproductive parameters of Holstein dairy cows in Egypt: potential biomarkers.BMC veterinary research · 2025Article
- Thermal Stress Response Profiling Reveals Adaptive Advantages of Indigenous Hercegovačka and Dubska Pramenka Sheep.Animals : an open access journal from MDPI · 2025Article
- Microbiome composition and co-occurrence dynamics in wildMicrobiology spectrum · 2025Article
- Rumination Time, Reticulorumen Temperature, and Activity in Relation to Postpartum Health Status in Dairy Cows During Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Metagenomic analysis reveals microbial drivers of heat resistance in dairy cattle.Animal microbiome · 2025Article
- Breed-Specific Responses and Ruminal Microbiome Shifts in Dairy Cows Under Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Stochasticity Highlights the Development of Both the Gastrointestinal and Upper-Respiratory-Tract Microbiomes of Neonatal Dairy Calves in Early Life.Animals : an open access journal from MDPI · 2025Article
- Role of micronutrients in production and reproduction of farm animals under climate change scenario.Tropical animal health and production · 2025Review
- Prolactin and heat stress; focus on domestic ruminants.Journal of animal science · 2025Review
- The epigenetic mechanisms of adaption to the hot and humid climate in Hu sheep (Ovis aries).Physiological reports · 2024Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbiome has emerged as a new player on behavior, physiology and stress because of its significant effects on the brain-gut axis. The aim of this study was to increase our understanding of brain-gut function in dairy cows. We investigated the effects of a heat-stress (HS) environment and individual differences of heat sensitivity (IH) on bovine physiological characteristics and microbial composition. Results indicate that both HS and IH increased rectal temperature (RT) (P < 0.05). An HS environment increased plasma, as well as milk cortisol and cytokines in plasma; however, it decreased plasma, and milk oxytocin, triiodothyronine, and thyroxine (P < 0.05) levels. Exposure to an HS environment reduced the diversity of the fecal microbial population, and resulted in a higher expression of diseases, the environmental adaptation pathway, and the immune related pathway, whereas it lowered the expression of metabolic pathways (P < 0.05). High heat sensitive cows have upregulated metabolisms, environmental adaptation and cellular process pathways, and a downregulated neurodegenerative disease pathway (P < 0.05). Thus, we conclude that exposure to an HS environment modulates physiological characteristics, which may interplay with microbial activity, and in turn, alter the circulation levels of cytokines, implicating the role of the brain-gut axis in dairy cows. The HS environment affected physiological characteristics, cytokine levels, and microbial composition, but IH influenced RT and fecal microbial functions.
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