Evidence map›Paper›PMID 30279365›Full record

ArticleInternational journal of molecular sciences2018

Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells.

Yuli C Chang, Yao Fong, Eing-Mei Tsai, Ya-Gin Chang, Han Lin Chou, Chang-Yi Wu, Yen-Ni Teng, Ta-Chih Liu, Shyng-Shiou Yuan, Chien-Chih Chiu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  6. Article
  7. Anti‑epileptic mechanism of isopimaric acid fromExperimental and therapeutic medicine · 2024
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  13. Review
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  17. Review
  18. Article
  19. Article
  20. The Phenoxyphenol Compound diTFPP Mediates Exogenous CAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yuli C ChangDepartment of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yuli33@ms28.hinet.net.
Yao FongChest Surgery, Chi-Mei Medical Center, Yung Kang City, Tainan 901, Taiwan. yaou.fong@msa.hinet.net.
Eing-Mei TsaiGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. tsaieing@yahoo.com.
Ya-Gin ChangDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yaginchang@hotmail.com.tw.
Han Lin ChouDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. d992050005@student.nsysu.edu.tw.
Chang-Yi WuDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. cywu@mail.nsysu.edu.tw.
Yen-Ni TengDepartment of Biological Sciences and Technology, National University of Tainan, Tainan 700, Taiwan. tengyenni@mail.nutn.edu.tw.
Ta-Chih LiuDepartment of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. d730093@cc.kmu.edu.tw.
Shyng-Shiou YuanTranslational Research Center, Cancer Center, Department of Medical Research, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yuanssf@ms33.hinet.net.
Chien-Chih ChiuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. cchiu@kmu.edu.tw.ORCID 0000-0001-7307-2468
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWChi Mei Medical Center · TWNational University of Tainan · TW

Funding

ChiMei-KMU Joint Research Project 104CMKMU006Kaohsiung Medical University KMU-TP105A07Ministry of Science and Technology, Taiwan MOST106-2320-B-037-012Ministry of Science and Technology, Taiwan MOST107-2320-B-037-023NSYSU-KMU NSYSU-KMU106-P019NSYSU-KMU NSYSU-KMU107-P002
6 · The paper itself

Abstract

Ceramides, abundant sphingolipids on the cell membrane, can act as signaling molecules to regulate cellular functions including cell viability. Exogenous ceramide has been shown to exert potent anti-proliferative effects against cancer cells, but little is known about how it affects reactive oxygen species (ROS) in lung cancer cells. In this study, we investigated the effect of

Indexed as

ApoptosisCell Cycle CheckpointsCell Line, TumorCell MovementCell ProliferationCeramidesG1 PhaseHumansLung NeoplasmsModels, BiologicalNeoplasm InvasivenessReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2CeramidesReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2apoptosisC8-ceramidecyclin D1lung cancerROSSOD switch

Identifiers

PMID30279365
PMCPMC6213533
OpenAlexW2895199722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.