Evidence map›Paper›PMID 30279333›Full record

Trial reportNutrients2018

Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption.

Xiaoqin Li, Jiawei Yin, Yalun Zhu, Xiaoqian Wang, Xiaoli Hu, Wei Bao, Yue Huang, Liangkai Chen, Sijing Chen, Wei Yang and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06513026 (Milk for Diabetes Prevention), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06513026 narecruitingnot on this mapstarted 2026, after this paper: background citation

Milk for Diabetes Prevention

TypeinterventionalSponsorAlbert Einstein College of MedicineRan2026 to 2028Enrolled40ConditionsLactose Intolerance, Lactose Intolerant, Lactase Persistence, Pre-DiabetesArmsLactose-Containing Milk, Lactose-Free Milk
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 49 citations in OpenAlex.

  1. Consumption of yacon flour and energy-restricted diet increased the relative abundance of intestinal bacteria in obese adults.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
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  8. Microbiology spectrum · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Xiaoqin LiDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. immary@163.com.
Jiawei YinDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. m201575208@hust.edu.cn.
Yalun ZhuDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. 15926237664@163.com.
Xiaoqian WangDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. M201675194@hust.edu.cn.
Xiaoli HuDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. M201675193@hust.edu.cn.
Wei BaoDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. wei-bao@uiowa.edu.ORCID 0000-0002-7301-5786
Yue HuangDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. hyhy199310@163.com.
Liangkai ChenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. D201678154@hust.edu.cn.
Sijing ChenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. sijingchen19@sina.com.
Wei YangDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yw8278@hotmail.com.
Zhilei ShanDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. zshan@hsph.harvard.edu.
Liegang LiuDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. lgliu@mails.tjmu.edu.cn.ORCID 0000-0002-7029-1224
Huazhong University of Science and Technology · CNHarvard University · USUniversity of Iowa · US

Funding

Chinese Nutrition Society Research Fund CNS-2015National Key Research and Development Program of China 2017YFC1600500National Natural Science Foundation of China 81703214
6 · The paper itself

Abstract

The aim of this study was to compare the impact of whole milk supplementation on gut microbiota and cardiometabolic biomarkers between lactose malabsorbers (LM) and absorbers (LA). We performed a pair-wise intervention study of 31 LM and 31 LA, 1:1 matched by age, sex, body mass index, and daily dairy intake. Subjects were required to add 250 mL/day whole milk for four weeks in their routine diet. At the beginning and the end of the intervention period, we collected data on gut microbiota and cardiometabolic biomarkers. Whole milk supplementation significantly increased Actinobacteria (

Indexed as

ActinobacteriaAdultAnimalsBifidobacteriumBiomarkersDietFecesFemaleGastrointestinal MicrobiomeHumansLactose IntoleranceMaleMilkYoung AdultBiomarkersBifidobacteriumgut microbiotalactose malabsorptionmilkshort-chain fatty acids

Identifiers

PMID30279333
PMCPMC6213503
OpenAlexW2895314748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.