Evidence map›Paper›PMID 30279285›Full record

ArticlemBio2018

A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion.

Bradley I Coleman, Sudeshna Saha, Seiko Sato, Klemens Engelberg, David J P Ferguson, Isabelle Coppens, Melissa B Lodoen, Marc-Jan Gubbels

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Physiology of invasiveFrontiers in cellular and infection microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Animal venoms: a novel source of anti-Frontiers in pharmacology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. The interaction between free CaParasitology research · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Ferlins and TgDOC2 inLife (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Bradley I Coleman *Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Sudeshna Saha *Department of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
Seiko SatoDepartment of Molecular Biology & Biochemistry and the Institute for Immunology, University of California, Irvine, California, USA.
Klemens EngelbergDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA.
David J P FergusonNuffield Department of Clinical Laboratory Science, University of Oxford John Radcliffe Hospital, Oxford, United Kingdom.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Melissa B LodoenDepartment of Molecular Biology & Biochemistry and the Institute for Immunology, University of California, Irvine, California, USA.
Marc-Jan GubbelsDepartment of Biology, Boston College, Chestnut Hill, Massachusetts, USA gubbelsj@bc.edu.
Boston College · USUniversity of California, Irvine · USJohn Radcliffe Hospital · GBJohns Hopkins University · US

Funding

Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
The Ca2+-sensing machinery operating on exocytosis in ToxoplasmaR01AI122923 · NIAID · BOSTON COLLEGE · PI GUBBELS, MARC-JAN · 2016 to 2020
$2.0M
The role of the DOC2.1 protein in Toxoplasma gondii Ca2+- dependent exocytosisR21AI099658 · NIAID · BOSTON COLLEGE · PI GUBBELS, MARC-JAN · 2013 to 2014
$419k
Molecular Discovery and Characterization within Toxoplasma Egress PathwaysF32AI108251 · NIAID · BOSTON COLLEGE · PI COLEMAN, BRADLEY IAN · 2014 to 2014
$55k
HSRD VA RRP 12-175NIAID NIH HHS F32 AI108251NIAID NIH HHS R01 AI060767NIAID NIH HHS R01 AI122923NIAID NIH HHS R21 AI099658
6 · The paper itself

Abstract

Invasion of host cells by apicomplexan parasites such as

Indexed as

CalciumCell LineGene Knockdown TechniquesGenome, ProtozoanHost-Parasite InteractionsHumansMembrane ProteinsProtozoan ProteinsToxoplasmaCalciumMembrane ProteinsProtozoan ProteinsROP 1 protein, Toxoplasma gondiicalciumferlinmicronemesprotein secretionrhoptriesToxoplasma gondii

Identifiers

PMID30279285
PMCPMC6168857
OpenAlexW2950790625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.