Evidence map›Paper›PMID 30279280›Full record

ArticlemBio2018

SsaV Interacts with SsaL to Control the Translocon-to-Effector Switch in the

Xiu-Jun Yu, Grzegorz J Grabe, Mei Liu, Luís Jaime Mota, David W Holden

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Roles of SPI-2 T3SS effectors in virulence ofFrontiers in veterinary science · 2025
    Article
  7. Article
  8. FlaG competes with FliS-flagellin complexes for access to FlhA in the flagellar T3SS to controlProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Infection and immunity · 2024
    Article
  10. Modulation ofmBio · 2024
    Article
  11. bioRxiv : the preprint server for biology · 2024
    Article
  12. TheMicrobiology (Reading, England) · 2023
    Article
  13. BopN is a Gatekeeper of theMicrobiology spectrum · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Xiu-Jun YuMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom x.yu@imperial.ac.uk d.holden@imperial.ac.uk.
Grzegorz J GrabeMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Mei LiuMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Luís Jaime MotaUCIBIO-REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (FCT NOVA), Caparica, Portugal.
David W HoldenUCIBIO-REQUIMTE, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (FCT NOVA), Caparica, Portugal x.yu@imperial.ac.uk d.holden@imperial.ac.uk.
Imperial College London · GBRede de Química e Tecnologia · PTUniversidade Nova de Lisboa · PT

Funding

Medical Research Council MR/K027077/1Wellcome Trust
6 · The paper itself

Abstract

Nonflagellar type III secretion systems (nf T3SSs) form a cell surface needle-like structure and an associated translocon that deliver bacterial effector proteins into eukaryotic host cells. This involves a tightly regulated hierarchy of protein secretion. A switch involving SctP and SctU stops secretion of the needle protein. The gatekeeper protein SctW is required for secretion of translocon proteins and controls a second switch to start effector secretion.

Indexed as

Gene Expression Regulation, BacterialGenomic IslandsProtein Interaction MappingAmino Acid SubstitutionBacterial ProteinsDNA Mutational AnalysisHydrogen-Ion ConcentrationProtein BindingProtein MultimerizationType III Secretion SystemsBacterial ProteinsSsaL protein, Salmonella typhimuriumType III Secretion SystemseffectorSalmonellasecretion switchtranslocontype III secretion

Identifiers

PMID30279280
PMCPMC6168863
OpenAlexW2895441437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.