ArticleJournal of the American Society of Nephrology : JASN2018
Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Elevated serum soluble α3(IV)NC1 correlates with kidney injury and worse outcome in patients with anti-glomerular basement membrane disease.Frontiers in immunology · 2026Article
- Anti-glomerular basement membrane disease-treatment standard.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- The multiple autoantibodies in anti-GBM disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Basement membranes in lung development, disease, and repair.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Anti-GBM antibody in a patient with diabetic nephropathy; all that glitters is not gold.Journal of nephrology · 2024Article
- High-resolution epitope mapping of commercial antibodies to ANCA antigens by yeast surface display.Journal of immunological methods · 2024Article
- Pediatric double-seropositive anti-glomerular basement membrane antibody disease: A case report and literature review.Clinical nephrology. Case studies · 2024Article
- Autoantibodies against laminin-521 are pathogenic in anti-glomerular basement membrane disease.Kidney international · 2023Article
- Glomerulonephritis: immunopathogenesis and immunotherapy.Nature reviews. Immunology · 2023Review
- Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4Frontiers in immunology · 2022Article
- Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.The Journal of biological chemistry · 2020Article
- ANCA-associated vasculitis.Nature reviews. Disease primers · 2020Review
- The glomerular crescent: triggers, evolution, resolution, and implications for therapy.Current opinion in nephrology and hypertension · 2020Review
- Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study.Journal of clinical medicine · 2020Article
- Biallelic Deletion ofInternational journal of molecular sciences · 2019Article
- Peroxidasin Is a Novel Target of Autoantibodies in Lupus Nephritis.Kidney international reports · 2019Article
- Peroxidasin-a Novel Autoantigen in Anti-GBM Disease?Journal of the American Society of Nephrology : JASN · 2018Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGoodpasture syndrome (GP) is a pulmonary-renal syndrome characterized by autoantibodies directed against the NC1 domains of collagen IV in the glomerular and alveolar basement membranes. Exposure of the cryptic epitope is thought to occur
methodsWe used ELISA and competitive binding assays to assess the presence and specificity of autoantibodies in serum from patients with GP and healthy controls. Peroxidasin activity was fluorometrically measured in the presence of partially purified IgG from patients or controls. Clinical disease severity was gauged by Birmingham Vasculitis Activity Score.
resultsWe detected anti-peroxidasin autoantibodies in the serum of patients with GP before and at clinical presentation. Enriched anti-peroxidasin antibodies inhibited peroxidasin-mediated hypobromous acid production
conclusionsAnti-peroxidasin antibodies, which would previously have been mischaracterized, are associated with pulmonary-renal syndromes, both before and during active disease, and may be involved in disease activity and pathogenesis in some patients.
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