Evidence map›Paper›PMID 30279224›Full record

ArticleGenome research2018

Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in

Robin L Armstrong, Taylor J R Penke, Brian D Strahl, A Gregory Matera, Daniel J McKay, David M MacAlpine, Robert J Duronio

Open access · greenAbstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  9. Genes & development · 2024
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  12. Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Robin L Armstrong *Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Taylor J R Penke *Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Brian D StrahlCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
A Gregory MateraCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Daniel J McKayCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
David M MacAlpineDepartment of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA.
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
University of North Carolina at Chapel Hill · USDuke University · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Chromatin-mediated mechanisms of genome integrityR35GM127062 · NIGMS · DUKE UNIVERSITY · PI David M MacAlpine · 2018 to 2026
$3.7M
Regulation of Metazoan DNA Replication by ChromatinR01GM124201 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J · 2018 to 2021
$1.2M
Chromatin architecture defines DNA replication originsR01GM104097 · NIGMS · DUKE UNIVERSITY · PI MACALPINE, DAVID M · 2013 to 2016
$1.2M
Epigenetic control of metazoan transcription and pre-mRNA processing by histone PTMsR01GM129132 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATERA, A. GREGORY · 2018 to 2019
$899k
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
Investigating the Role of Histone Modifications in Heterochromatin FormationF31GM115194 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PENKE, TAYLOR JOEL RICHARD · 2015 to 2017
$84k
NCI NIH HHS P30 CA016086NIGMS NIH HHS F31 GM115194NIGMS NIH HHS R01 GM104097NIGMS NIH HHS R01 GM124201NIGMS NIH HHS R01 GM129132NIGMS NIH HHS R35 GM127062NIGMS NIH HHS R35 GM128851NIGMS NIH HHS T32 GM007092NIH HHS S10 OD018164
6 · The paper itself

Abstract

Chromatin structure has emerged as a key contributor to spatial and temporal control over the initiation of DNA replication. However, despite genome-wide correlations between early replication of gene-rich, accessible euchromatin and late replication of gene-poor, inaccessible heterochromatin, a causal relationship between chromatin structure and replication initiation remains elusive. Here, we combined histone gene engineering and whole-genome sequencing in

Indexed as

Chromatin Assembly and DisassemblyDNA Replication TimingAnimalsChromosomes, InsectDrosophilaFemaleHeterochromatinHistonesMaleMutationTranscriptional ActivationX ChromosomeHeterochromatinHistones

Identifiers

PMID30279224
PMCPMC6211642
OpenAlexW2895188054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.