Evidence map›Paper›PMID 30279207›Full record

ArticleBioscience reports2018

Specific expression of lncRNA RP13-650J16.1 and TCONS_00023979 in prostate cancer.

Xiaochen Zhou, Qiong Chen, Haolin Wang, Cheng Zhang, Bin Fu, Gongxian Wang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Xiaochen ZhouDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Qiong ChenDepartment of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Haolin WangDepartment of Urology, Yichun People's Hospital, Yichun 336000, Jiangxi, China.
Cheng ZhangDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Bin FuDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Gongxian WangDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China wanggx-mr@126.com.
Nanchang University · CNFirst Affiliated Hospital of Nanchang University · CNSecond Military Medical University · CNYichun University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to explore the expression profile and the potential regulatory mechanism of two long non-coding RNAs (lncRNAs) (RP13-650J16.1 and TCONS_00023979) in prostate cancer (PCa). Expression profile of lncRNAs in PCa and paracancerous tissues were investgated by the high-throughput gene chip technology. Specific siRNA of RP13-650J16.1 or TCONS_00023979 was transfected into DU145 cells. Then, the relative expression of RP13-650J16.1, receptor-associated coactivator 3 (RAC3), promyelocytic leukemia (PML), and TCONS_00023979 was detected by quantitative real-time PCR and Western blotting. MTT assay was used to detect the proliferation of DU145 cells. The migration ability of DU145 cells was measured by Transwell chambers. Single cell proliferation and clonogenic ability were detected by plate clone formation assay. RP13-650J16.1 and RAC3 expression was up-regulated, and TCONS_00023979 and PML expression was down-regulated in PCa tissues. Silencing RP13-650J16.1 could decrease RAC3 expression, and knockout of TCONS_00023979 also reduced PML expression. Moreover, the ability of proliferation, migration, and colony formation of DU145 cells was decreased after transfected with si-RP13-650J16.1, while these abilities were increased after transfected with si-TCONS_00023979. Collectively, our findings demonstrated that RP13-650J16.1 might be an oncogene and TCONS_00023979 might be an antioncogene in PCa.

Indexed as

Gene Expression Regulation, NeoplasticCell Line, TumorCell MovementCell ProliferationHumansMaleNeoplasm ProteinsPromyelocytic Leukemia ProteinProstateProstatic NeoplasmsProto-Oncogene Proteins c-bcl-2rac GTP-Binding ProteinsRNA, Long NoncodingRNA, Small InterferingSignal TransductionTumor MicroenvironmentBCL2 protein, humanNeoplasm ProteinsPML protein, humanPromyelocytic Leukemia ProteinProto-Oncogene Proteins c-bcl-2RAC3 protein, humanrac GTP-Binding ProteinsRNA, Long NoncodingRNA, Small InterferingDU145prostate cancerRP13-650J16.1TCONS_00023979

Identifiers

PMID30279207
PMCPMC6209587
OpenAlexW2894920649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.